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Transcriptomic and Proteomic Profiling Reveal Immune and Metabolic Dysregulation in the Colonic Mucosa of People with HIV with Incomplete Immune Recovery

ABSTRACT: Background: People living with HIV are called immunological non-responders (INR) when their CD4+ T cell count is not restored to immunocompetent levels, despite successful viral suppression. INR have increased risk of progression to AIDS, non-AIDS related morbidity, and death. Impaired mucosal barrier function is a prevailing hypothesis for why INR among people with HIV (PWH) have persistently low CD4+ T cell counts.Objective: To understand the molecular mechanisms behind incomplete immune recovery in INR, we analysed gene regulation and protein expression in gut tissues from INR, immunological responders (IR), and healthy controls (HC).

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ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Animesh Sharma

LAB HEAD: Mari Kaarbø

PROVIDER: PXD041255 | Pride | 2025-09-09

REPOSITORIES: Pride

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			Action	DRS
	20190603_MariK_DDA_01.raw	Raw
	20190603_MariK_DDA_02.raw	Raw
	20190603_MariK_DDA_03.raw	Raw
	20190603_MariK_DDA_04.raw	Raw
	20190603_MariK_DDA_05.raw	Raw

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