Dataset Information

Hippocampus LC-MS experiment from Men1-CcKO mice and the controls

ABSTRACT: hippocampus dissection and conducted the LC-MS experiment in double-blind conditions

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Shuzhong Wang

LAB HEAD: Jie Zhang

PROVIDER: PXD042795 | Pride | 2024-07-03

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	ZK-1_Slot2-11_1_3103.d.rar	Other
	ZK-2_Slot2-12_1_3105.d.rar	Other
	ZK-3_Slot2-13_1_3107.d.rar	Other
	ZK-4_Slot2-14_1_3109.d.rar	Other
	ZK-5_Slot2-15_1_3111.d.rar	Other

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Publications

Menin Deficiency Induces Autism-Like Behaviors by Regulating Foxg1 Transcription and Participates in Foxg1-Related Encephalopathy.

Zhuang Kai K Leng Lige L Su Xiao X Wang Shuzhong S Su Yuemin Y Chen Yanbing Y Yuan Ziqi Z Zi Liu L Li Jieyin J Xie Wenting W Yan Sihan S Xia Yujun Y Wang Han H Li Huifang H Chen Zhenyi Z Yuan Tifei T Zhang Jie J

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20240406 24

FOXG1 syndrome is a developmental encephalopathy caused by FOXG1 (Forkhead box G1) mutations, resulting in high phenotypic variability. However, the upstream transcriptional regulation of Foxg1 expression remains unclear. This report demonstrates that both deficiency and overexpression of Men1 (protein: menin, a pathogenic gene of MEN1 syndrome known as multiple endocrine neoplasia type 1) lead to autism-like behaviors, such as social defects, increased repetitive behaviors, and cognitive impair ...[more]

PMID: 38582517

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