Hydrogen Deuterium Exchange of PIKfyve construct with PI3P vesicles and inhibitors

ABSTRACT: We used HDXMS to study the confomational changes induced in a PIKfyve construct upon binding PI3P membrane and a variety of inhibitors. Here we showed a significant protection in deuterium exchange upon binding all inhibitors, and regions of protection and exposure upon binding PI3P membrane.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: John Burke  

LAB HEAD: Dr. John E. Burke

PROVIDER: PXD044706 | Pride | 2025-10-15

REPOSITORIES: Pride