Dataset Information

Circulating levels of the proinflammatory monomeric isoform of C-reactive protein (mCRP) correlate with intra-tumoral mCRP abundance in stage II-III colon cancer patients

ABSTRACT: Elevated levels of circulating C-reactive protein (CRP) are associated with worse outcome for patients with colorectal cancer (CRC). Monomeric CRP (mCRP) has been demonstrated in tissues of various diseases, including colon cancer (CC). mCRP possesses proinflammatory properties and potentially contributes to tumour-promoting inflammation. Although considered tissue-based, mCRP can exist in the circulation bound to membranes or as aggregates. This project aimed to detect and quantify circulating mCRP in CC patients by mass spectrometry.

INSTRUMENT(S): Bruker software

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood Plasma

DISEASE(S): Colorectal Cancer

SUBMITTER: Manuel Ramirez

LAB HEAD: Anniken Jørlo Fuglestad

PROVIDER: PXD046746 | Pride | 2025-06-16

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	MR_230912_Fuglestad_124_Slot2-20_1_11868.mgf	Mgf
	MR_230912_Fuglestad_167_Slot2-21_1_11870.mgf	Mgf
	MR_230912_Fuglestad_186_Slot2-22_1_11872.mgf	Mgf
	MR_230912_Fuglestad_203_Slot2-23_1_11874.mgf	Mgf
	MR_230912_Fuglestad_280_Slot2-24_1_11876.mgf	Mgf

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Publications

Circulating Levels of the Proinflammatory Monomeric Isoform of C-Reactive Protein (mCRP) Correlate with Intra-Tumoral mCRP Abundance in Stage II-III Colon Cancer Patients.

Fuglestad Anniken Jørlo AJ Bousquet Paula Anna PA Køstner Anne Helene AH Meltzer Sebastian S Kleist Britta B Ree Anne Hansen AH Rajab Ibraheem M IM Potempa Lawrence A LA Fernandez-Botran Rafael R Kersten Christian C

Journal of inflammation research 20250603

<h4>Purpose</h4>Colorectal cancer (CRC) is the third most common type of cancer worldwide. The link between inflammation and CRC is well established. Elevated levels of C-reactive protein (CRP) upon diagnosis is a known negative prognostic factor for CRC patients. Monomeric CRP (mCRP) has been demonstrated in tissues of several diseases associated with inflammation, including colon cancer (CC). mCRP possesses proinflammatory properties and is a possible mediator of tumor-promoting inflammation. ...[more]

PMID: 40487285

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