Metabolisme of artemisinin-resistant falciparum malaria parasites: are apicoplast and mitochondrion pathways key targets?

ABSTRACT: In the context of artemisinin resistance, the objective of the project was to evaluate the role of apicoplast and mitochondrion pathways during the parasite quiescent state induced by dihydroartemisinin (DHA) treatment. We analysed the proteome of artemisinin-resistant parasites in two conditions: after 6 h of DHA treatment or DMSO treatment (as control condition) at the ring stage (obtained by D-sorbitol synchronization).

INSTRUMENT(S):

ORGANISM(S): Plasmodium Falciparum

TISSUE(S): Permanent Cell Line Cell

DISEASE(S): Plasmodium Falciparum Malaria

SUBMITTER: Marlene Marcellin  

LAB HEAD: Odile Schiltz

PROVIDER: PXD048354 | Pride | 2025-05-06

REPOSITORIES: Pride