Proteomics

Dataset Information

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Mucin drives human gut microbial ecological interactions in an in vitro synthetic community


ABSTRACT: In this study, we created a synthetic mucin-degrading microbial community to specifically study mucin-driven ecological interactions in vitro. The synthetic community consisted of primary mucin degraders and cross-feeders. We tracked community composition and dynamics and the mucin-degrading enzymes that were produced.

INSTRUMENT(S):

ORGANISM(S): Bacteroides Caccae Atcc 43185 Agathobacter Rectalis Atcc 33656 Akkermansia Muciniphila Atcc Baa-835 [ruminococcus] Torques Atcc 27756 Anaerostipes Caccae Dsm 14662 Phocaeicola Vulgatus Atcc 8482 Anaerobutyricum Hallii Dsm 3353 Desulfovibrio Piger Atcc 29098 Bacteroides Fragilis (strain Atcc 25285 / Nctc 9343) Faecalibacterium Prausnitzii A2-165 Ruminococcus Gnavus Atcc 29149 Roseburia Intestinalis L1-82 Methanobrevibacter Smithii Dsm 11975 Blautia Hydrogenotrophica Dsm 10507 Bacteroides Thetaiotaomicron (strain Atcc 29148 / Dsm 2079 / Nctc 10582 / E50 / Vpi-5482)

SUBMITTER: Sjef Boeren  

LAB HEAD: Sjef Boeren

PROVIDER: PXD051481 | Pride | 2025-03-12

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MQ_result_RA503-518_RA568-583.zip Other
RA503_MDSC_t72_R1.raw Raw
RA504_MDSC_t72_R2.raw Raw
RA505_MDSC_t72_R3.raw Raw
RA506_MDSC_t96_R1.raw Raw
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Publications

Mucin-driven ecological interactions in an in vitro synthetic community of human gut microbes.

Berkhout Maryse D MD   Ioannou Athanasia A   de Ram Carol C   Boeren Sjef S   Plugge Caroline M CM   Belzer Clara C  

Glycobiology 20241201 12


Specific human gut microbes inhabit the outer mucus layer of the gastrointestinal tract. Certain residents of this niche can degrade the large and complex mucin glycoproteins that constitute this layer and utilise the degradation products for their metabolism. In turn, this microbial mucin degradation drives specific microbiological ecological interactions in the human gut mucus layer. However, the exact nature of these interactions remains unknown. In this study, we designed and studied an in v  ...[more]

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