Proteomics

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Proteome analysis of the relationship between atopic dermatitis and environmental hazardous substances

ABSTRACT: Several studies have reported an association between phthalate exposure and an increased risk of atopic dermatitis (AD). However, the molecular mechanism underlying this phenomenon in children remains unknown. In this study, we investigated the effect of Dibutyl Phthalate (DBP), one of the phthalate, on AD development and explored the potential mechanisms using proteomics.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Jeonghun Yeom  

LAB HEAD: Jeonghun Yeom

PROVIDER: PXD053710 | Pride | 2026-06-20

REPOSITORIES: Pride

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Dataset's files

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Action DRS
221213-Exposome_A08-068-C_EX_1ul_zSWATH_37m_r01.wiff Wiff
221213-Exposome_A08-068-C_EX_1ul_zSWATH_37m_r01.wiff.scan Wiff
221213-Exposome_A09-012-C_EX_1ul_zSWATH_37m_r01.wiff Wiff
221213-Exposome_A09-012-C_EX_1ul_zSWATH_37m_r01.wiff.scan Wiff
221213-Exposome_A09-013-C_EX_1ul_zSWATH_37m_r01.wiff Wiff
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Publications

Dibutyl phthalate induces atopic dermatitis via semaphorin-plexin signaling and IL-5: ECHO-COCOA study.

Kang Mi-Jin MJ   Yeom Jeonghun J   Park Yong Joo YJ   Song Ah-Yoon AY   Im Hosub H   Kim Yanghee Y   Kim Jeong-Hyun JH   Yoo Hyun Ju HJ   Seong Hoon Je HJ   Lee Seung-Hwa SH   Kim Hyo-Bin HB   Yang Song-I SI   Lee So-Yeon SY   Ahn Kangmo K   Kim Kyung Won KW   Shin Youn Ho YH   In Suh Dong D   Choi Eom Ji EJ   Hong Soo-Jong SJ  

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20251001 10

<h4>Background</h4>Several studies have reported an association between phthalate exposure and an increased risk of atopic dermatitis (AD). However, the molecular mechanism underlying this phenomenon in children remains unknown.<h4>Objectives</h4>In this study, we investigated the effect of dibutyl phthalate (DBP) on AD development from a birth cohort and explored the potential mechanisms using multi-omics.<h4>Methods</h4>Urinary concentrations of mono-n-butyl phthalate (MnBP) and mono-isobutyl  ...[more]

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