Proteomics

Dataset Information

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Mouse Prefontal Cortex Astrocyte Proteome


ABSTRACT: Anxiety disorders are among the most common and disabling mental health disorders worldwide with inadequate therapeutic options. Numerous clinical and research studies indicate essential neuronal contribution to anxiety, yet the mechanisms of non-neuronal cells governing this emotional state remain poorly understood. Here, we show that non-neuronal astrocytes in the medial prefrontal cortex (mPFC) encode anxiogenic environmental cues. Silencing mPFC astrocyte Ca2+ signaling heightens anxiety-like behavior and disrupts the balance between excitatory and inhibitory neuronal population activity. Moreover, this effect is differentially pronounced across behaviorally tuned neuronal subpopulations on single cell and network levels. Using cell type-specific proximity-dependent biotinylation approaches, we further identified significant protein expression changes in astrocytes and at the astrocyte-neuron interface within the mPFC.

INSTRUMENT(S): timsTOF Pro 2

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Yanqi Tan  

LAB HEAD: Jonathan Sweedler

PROVIDER: PXD055874 | Pride | 2025-07-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
CalEx1.d.zip Other
CalEx2.d.zip Other
CalEx3.d.zip Other
CalEx4.d.zip Other
CalEx5.d.zip Other
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