Dataset Information
M1 polyubiquitin targets in the hippocampus of young and aged male rats following contextual fear conditioning
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Layer Of Hippocampus, Brain
DISEASE(S): Post-traumatic Stress Disorder
SUBMITTER: 
Keith Ray
LAB HEAD: Timothy J. Jarome
PROVIDER: PXD056433 | Pride | 2026-06-29
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 240605_Jarome_AN1_01.msf | Msf | |||
| 240605_Jarome_AN1_01.msfView | Msf | |||
| 240605_Jarome_AN1_01.mzML | Mzml | |||
| 240605_Jarome_AN1_01.mzid.gz | Mzid | |||
| 240605_Jarome_AN1_01.pdResult | Other |
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Publications
Increasing degradation-independent linear polyubiquitin in the hippocampus enhances memory in young adult but not aged rats.
Neurobiology of learning and memory 20250620
Age-related memory loss affects approximately 40% of the world's population after the age of 65 and is a significant risk factor for the development of dementia and Alzheimer's Disease (AD). Numerous studies have reported that late in life there decreases in the function of the ubiquitin-proteasome system, the main regulator of protein degradation in cells that is also critically involved in memory formation. However, ubiquitin can mark proteins for fates other than destruction by the proteasome ...[more]
