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Temporally graded M1 polyubiquitin targets in the male amygdala following contextual fear conditioning

ABSTRACT: Temporally graded M1 polyubiquitin targets in the male amygdala following contextual fear conditioning

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain, Amygdala

DISEASE(S): Post-traumatic Stress Disorder

SUBMITTER: Keith Ray

LAB HEAD: Timothy J.

PROVIDER: PXD069050 | Pride | 2026-05-02

REPOSITORIES: Pride

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			Action	DRS
	250822_BrieMM_01_01.msf	Msf
	250822_BrieMM_01_01.msfView	Msf
	250822_BrieMM_01_01.mzML	Mzml
	250822_BrieMM_01_01.mzid	Mzid
	250822_BrieMM_01_01.pdResult	Other

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Publications

Temporal- and sex-specific changes in proteasome-dependent and independent polyubiquitination in the amygdala during fear memory formation.

Brown Brieann B Preveza Natalie N Jones Gaurav G Turner Meagan M Ray W Keith WK Jarome Timothy J TJ

Learning & memory (Cold Spring Harbor, N.Y.) 20260331 4

Strong evidence has emerged over the last two decades implicating proteasome-dependent and independent protein polyubiquitination in the memory consolidation process. Recently, it was shown that multiple forms of polyubiquitination, including proteasome-dependent K48 and proteasome-independent M1 polyubiquitination, regulate fear memory formation in a sex-dependent manner in the amygdala. However, prior work focused on single time points during the postlearning period, leaving questions about wh ...[more]

PMID: 41916668

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Temporally graded K48 polyubiquitin targets in the female amygdala following contextual fear conditioning

Project description:Temporally graded K48 polyubiquitin targets in the female amygdala following contextual fear conditioning

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Temporally graded M1 polyubiquitin targets in the female amygdala following contextual fear conditioning

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Temporally graded K48 polyubiquitin targets in the male amygdala following contextual fear conditioning

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Targets of K27 polyubiquitin in the female hippocampus following contextual fear conditioning

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K63 polyubiquitin targets in the hippocampus of male and female rats following contextual fear conditioning

Project description:This experiment examined K63 polyubiquitin protein targets in the male and female hippocampus after contextual fear conditioning. Samples were the CA1 region of the dorsal hippocampus collected from male and female Sprague-Dawley rats that were 8-9 weeks old. Samples were collected 1 hour after contextual fear conditioning (Trained) or from non-stimulated controls (Naïve).

2024-12-02 | PXD054726 | Pride

K63 polyubiquitin targets in the hippocampus of male and female rats following contextual fear conditioning

2024-12-02 | PXD054877 | Pride

Genome-wide maps of chromatin changes uppon contextual fear conditioning in mice

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-11-24 | E-GEOD-74971 | biostudies-arrayexpress

Microarray dataset of gene transcription in mouse microglia and peripheral monocytes in contextual fear conditioning

Project description:Using Illumina MouseWG-6v2 microarrays, we investigated the gene transcription changes in microglia and peripheral monocytes after contextual fear conditioning of C57BL/6J mice. Mice were trained with or without a single minimized footshock stimulation (0-s or 2-s, 0.4 mA) and re-exposed to the training context without footshock for three different durations 24 h later: 0 min (FS0), 3 min (FS3), or 30 min (FS30). Whole brain microglia and peripheral monocytes were prepared 24 h after re-exposure using a neural tissue dissociation kit, including non-footshock controls for two re-exposure durations (Con3 and Con30). The data can be valuable for researchers interested in glial cells and neurotransmission studies and are related to the research article “Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia”.

2022-10-28 | E-MTAB-12361 | biostudies-arrayexpress

Genome-wide maps of chromatin changes uppon contextual fear conditioning in mice (RNA-seq)

Project description:The ability to form memories is a prerequisite for an organismâs behavioural adaptation to environmental changes. At the molecular level, the acquisition and maintenance of memory requires changes in chromatin modifications. In an effort to unravel the epigenetic network underlying both short- and long-term memory, we examined chromatin modification changes in two distinct mouse brain regions, two cell-types, and three time-points before and after contextual learning. Here we show that histone modifications predominantly change during memory acquisition and correlate surprisingly little with changes in gene expression. While long-lasting changes are almost exclusive to neurons, learning-related histone modification and DNA methylation changes occur also in non-neuronal cell types, suggesting a functional role for non-neuronal cells in epigenetic learning. Finally, our data provides evidence for a molecular framework of memory acquisition and maintenance, wherein DNA methylation could alter the expression and splicing of genes involved in functional plasticity and synaptic wiring. We examined chromatin modification changes in two distinct mouse brain regions (CA1 and ACC), two cell-types (neurons, non-neurons), and three time-points before and after contextual learning (naive, 1h, 4w).

2015-11-24 | E-GEOD-74966 | biostudies-arrayexpress

RNA-seq analysis of contextual fear conditioning

Project description:This dataset constitutes the first RNA-seq study of gene expression following contextual fear conditioning in the mouse hippocampus. 15 total samples were analyzed, including animals trained in a contexual conditioning paradigm (FC) and controls. Tissue was collected at 30 minutes (FC), as well as 30 minutes after testing for retrieval of the memory (RT). Testing was performed at 24 hours after training over a 5-minute interval. Animals that were handled but not trained were dissected at the same time of day to control for variations due to circadian rhythms (CC3). The protocol was repeated over the course of 5 days to obtain 9 animals (2 hippocampi) per group, so that 5 independent FC experiments were represented in each time point and all animals for each group were dissected at the exactly the same time of day.

2015-07-22 | E-GEOD-63412 | biostudies-arrayexpress

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