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Identification of interactors of the Drosophila zinc finger protein hangover

ABSTRACT: The Drosophila melanogaster multi zinc finger protein hangover (hang) regulates responses to oxidative stress, heat shock and ethanol exposure by modulating transcript levels in adult fly heads. The hangover protein contains no less than 18 C2H2-type zinc fingers. These domains are prevalent among chromatin-regulating proteins, particularly transcription factors, where they typically mediate associations with DNA and transcriptional effectors. Here, we identify hangover-interacting proteins in order to shed light on its molecular function.

INSTRUMENT(S):

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

SUBMITTER: Ignasi Forne

LAB HEAD: Prof. Dr. Alexander Brehm

PROVIDER: PXD062946 | Pride | 2025-12-22

REPOSITORIES: Pride

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Publications

Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation.

Lenz Jonathan J Schmelzer Laura L Forné Ignasi I Nist Andrea A Imhof Axel A Stiewe Thorsten T Brehm Alexander A

Nucleic acids research 20251101 22

The RNA-binding protein Hangover (Hang) is essential for several stress responses in Drosophila melanogaster. Here, we discover a novel function of Hang in the regulation of gene expression. Hang binds to >2000 genes in the Drosophila genome and modulates transcription. We identify a diverse set of chromatin regulators as Hang interactors, including NSL, dMec, Sin3A, dREAM, and Ino80. Among these, the non-specific lethal complex (NSL) is the most prominent one. We show that Hang attenuates NSL-m ...[more]

PMID: 41404805

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2010-10-12 | E-GEOD-24618 | biostudies-arrayexpress

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seq-SDQ2946_HCP4_N2_Mxemb

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