Dataset Information

TMT-based quantitative proteomic profiling of brain tissue from multiparous and nulliparous 5xFAD mice

ABSTRACT: TMT-based quantitative proteomic profiling of brain tissue from multiparous and nulliparous 5xFAD mice

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Yang Renzhi

LAB HEAD: Hongsheng Zhang

PROVIDER: PXD064605 | Pride | 2026-06-08

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	Label_unadjDiff_mulitparity_con_all.xlsx	Xlsx
	PRIDE_Metadata_Table.csv	Csv
	Protein_Matrix_annotation.xlsx	Xlsx
	WAK20240927chenmn_wosp24320_60minTMT_1.raw	Raw
	WAK20240927chenmn_wosp24320_60minTMT_10.raw	Raw

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Publications

Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis.

Yang Renzhi R He Ying Y Pan Youkai Y Geng Aoyi A Huang Fang F Guo Kai K Zhang Hongsheng H

Immunity & ageing : I & A 20260329 1

BACKGROUND: Women have nearly twice the lifetime risk of Alzheimer’s disease (AD) as men. Hormonal and reproductive factors have been implicated; however, the role of parity, a female-specific experience, remains unknown. While epidemiological data suggest that high parity may increase the risk of dementia, the underlying biological mechanisms are unclear. METHODS: We investigated the impact of multiparity on AD pathology using 2-month-old female 5xFAD mice. Mice were assigned to a nulliparous ( ...[more]

PMID: 41906135

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