Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Pancreatic Ductal Cell, Cell Culture
DISEASE(S): Pancreatic Cancer
SUBMITTER: Miljan Kuljanin
LAB HEAD: Joseph Mancias
PROVIDER: PXD064874 | Pride | 2025-07-07
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
JM2964_Ser_1.mzTab | Mztab | |||
JM2964_Ser_1.raw | Raw | |||
JM2965_Ser_2.mzIdentML | Mzid | |||
JM2965_Ser_2.raw | Raw | |||
JM2966_Ser_3.mzIdentML | Mzid |
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Cell 20201102 5
Pancreatic ductal adenocarcinoma (PDAC) tumors have a nutrient-poor, desmoplastic, and highly innervated tumor microenvironment. Although neurons can release stimulatory factors to accelerate PDAC tumorigenesis, the metabolic contribution of peripheral axons has not been explored. We found that peripheral axons release serine (Ser) to support the growth of exogenous Ser (exSer)-dependent PDAC cells during Ser/Gly (glycine) deprivation. Ser deprivation resulted in ribosomal stalling on two of the ...[more]