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Gas plasma-induced bacterial PAMP release promotes skin cancer cell death

ABSTRACT: The aim of this study was to investigate plasma-induced bacterial PAMP release and their combination with direct gas plasma exposure in skin cancer cells in vitro. Supernatants of plasma-treated (pPAMP) and heat-inactivated (hPAMP) bacteria were analyzed using LC-MS/MS.

INSTRUMENT(S):

ORGANISM(S): Staphylococcus Aureus Staphylococcus Epidermidis Pseudomonas Aeruginosa

TISSUE(S): Cell Culture

SUBMITTER: Julia Berner

LAB HEAD: Sander Bekeschus

PROVIDER: PXD070469 | Pride | 2025-12-22

REPOSITORIES: Pride

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			Action	DRS
	bacterial_supernatant.msf	Msf
	checksum.txt	Txt
	hPAMP_1.raw	Raw
	hPAMP_2.raw	Raw
	hPAMP_3.raw	Raw

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Publications

Gas plasma-induced bacterial PAMP release promotes skin cancer cell death.

Berner Julia J Sieben Malin M Freund Eric E Schulan Paul P Miebach Lea L Bekeschus Sander S

Cell death & disease 20251204 1

Infected skin tumors are challenging to treat and frequently result in tumor progression, relapses, and post-surgical complications. Moreover, bacterial infections significantly contribute to tumor therapy resistance as they release tumor microenvironment (TME)-modulating molecules. Immune or cancer cells can recognize these pathogen-associated molecular patterns (PAMPs), initiating signaling and pro- or antitumoral response. Hence, understanding PAMPs in tumor therapy may improve the understand ...[more]

PMID: 41345386

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tyrosine kinase oxidation by gas plasma

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Cytosolic and plasma membrane proteome analysis of rice leaves in response to MSP1 treatment

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Physiological and transcriptional response of Bacillus cereus treated with low-temperature nitrogen gas plasma

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RD2-mediated regulation of gene expression following GAS exposure to human plasma

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Transcription profiling of human blood lymphoblasts purified at three time points from childhood ALL samples (0h, 6-8h, 24h after treatment with prednisolone

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