Comprehensive retinal characterization of myopic guinea pigs after PI3K/AKT inhibition via data-independent acquisition on an Orbitrap Exploris 480 mass spectrometer.

ABSTRACT: Myopia progression is driven by abnormal signaling pathways, particularly the PI3K/AKT pathway. Using a lens-induced myopia model in guinea pigs, we administered the PI3K/AKT inhibitor LY294002 via intravitreal injection and performed quantitative proteomic analysis with data-independent acquisition mass spectrometry. This study provides retinal proteomic data from normal, myopic, and drug-treated guinea pigs. It also establishes the first comprehensive retinal proteome database for guinea pig myopia, offering insights into myopia development and the role of the PI3K/AKT pathway in its progression.

INSTRUMENT(S):

ORGANISM(S): Cavia

TISSUE(S): Retina

DISEASE(S): Myopia

SUBMITTER: Chuen Lam  

LAB HEAD: Thomas LAM

PROVIDER: PXD074201 | Pride | 2026-03-23

REPOSITORIES: Pride