Sex differences in the gut microbiome
Ontology highlight
ABSTRACT: The gut microbiome is different between the sexes.Depleting androgen via castration changed the gut microbiome of male mice to be more similar to that of females and improved glucose metabolism, while reintroducing dihydrotestosterone (DHT) reversed these alterations. More importantly, the effects of androgen on glucose metabolism were largely abolished when the gut microbiome was depleted. Our study identifies the effects of androgen in deteriorating glucose homeostasis by modulating the gut microbiome, thereby contributing to the glucose metabolism difference between the sexes.
PROVIDER: PRJEB41747 | ENA |
REPOSITORIES: ENA
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