Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

16S rRNA ANALYSIS MOUSE MODEL OF FISH ALLERGY

ABSTRACT: META-GENOMIC ANALYSIS OF THE GUT MICROBIOTA IN A MOUSE MODEL OF FISH ALLERGY

PROVIDER: PRJEB90594 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Establishment of a murine model of beta-parvalbumin-induced fish allergy and proteomic profiling of immune cell activation using DIA-based ZenoSWATH-MS

Project description:Food allergy is an immune-mediated condition caused by hypersensitivity to food allergens, with fish allergens, particularly beta-parvalbumins (beta-PRVBs), being the most significant. While the only effective treatment is avoidance of the food allergen, the intracellular mechanisms of immune activation during allergen exposure are not well understood. This study aimed to investigate critical insights into immune cell activation in a newly proposed beta-PRVB-induced fish allergy model, with a particular focus on to explore the proteomic phenotype of splenocytes and T cell activation in response to the allergen. To establish a robust allergic response, mice were sensitized to beta-PRVB using aluminium hydroxide, a Th2-skewing adjuvant, (intraperitoneal injection) and subsequently challenged orally with beta-PRVB . This carefully designed protocol was designed to induce a Th2-type immune response, which was confirmed by detecting allergen-specific antibodies and cytokines. For proteomic analysis of the immune response, high-resolution quantitative proteomics data were generated using an advanced DIA-based ZenoSWATH-MS technology.

2025-05-13 | MSV000097859 | MassIVE

Fish allergy

Project description:Sensitization patterns to fish parvalbumins

| PRJEB46886 | ENA

Samples of murine food allergy model

Project description:Samples of murine food allergy model Raw sequence reads

| PRJNA853889 | ENA

SABioscience mouse PCR array of the ear tissues of Nickel allergy model

Project description:PCR array analysis was performed to investigate the expression of genes in the ear tissues of Ni allergy-induced miceand control mice. Ni model mouse n=3, control mouse n=3

2013-11-19 | E-GEOD-52466 | biostudies-arrayexpress

16S rRNA amplicons from fish farm for lump fish

Project description:16S rRNA amplicons from fish farm for lump fish Raw sequence reads

| PRJNA476040 | ENA

Expression data from allergy and non allergy humans

Project description:Expression data from allergy and non allergy humans

| PRJNA838997 | ENA

SABioscience mouse PCR array of the ear tissues of Nickel allergy model

Project description:PCR array analysis was performed to investigate the expression of genes in the ear tissues of Ni allergy-induced miceand control mice.

2013-11-19 | GSE52466 | GEO

CENAT-H.sapiens-Allergy-ded1

Project description:Comparison of gene expression profiles between pediatric patients with and without symptoms of cross-allergy (birch-apple syndrome).

2013-10-11 | E-MEXP-3633 | biostudies-arrayexpress

Proteomic characterization of major fish allergy responsive protein parvalbumins in Hilsa (Tenualosa ilisha): A commercially important fish in Southeast Asia

Project description:The protein parvalbumin (PRV)-beta (PRVB) is the primary cause behind food allergies to bony fish. Although PRVB is a well-characterized protein in many bony fishes, little is known about the hilsa, an anadromous fish with great economic importance and mostly found in Southeast Asia. In this study, we have characterized the hilsa PRV utilizing various proteomic approaches in response to two major riverine habitats and developmental stages. Unique peptide sets correspond to three different PRV isoforms were identified in hilsa muscle tissues. Label-free quantitative proteomic analysis coupled with ELISA revealed higher levels of PRVB in young fish comparative to the adult, irrespective of their riverine habitats. A comparative quantitative analysis of PRVB further demonstrated that hilsa had less PRVB than other commonly consumed freshwater fish species. Multiple reaction monitoring (MRM)-based targeted proteomic approach showed the potential of PRV as a marker protein for allergen quantitation and authenticating the presence of hilsa in a complex freshwater fish mixture. Our findings collectively offer fundamental knowledge on hilsa parvalbumins for further investigation on the food safety and quality evaluation of hilsa fish.

2025-01-07 | MSV000096794 | MassIVE

Skin inflammation exacerbates food allergy symptoms in epicutaneously sensitized mice

Project description:Cutaneous exposure to food antigen through impaired skin barrier has been shown to induce epicutaneous sensitization, and thereby cause IgE-mediated food allergy. We examined whether skin barrier impairment deteriorated food allergy symptoms in epicutaneously sensitized mice. To clarify the association between skin inflammation and food allergy symptoms, we analyzed gene expression at skin lesions using a GeneChip.

2017-06-30 | GSE95278 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data