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Gene expression profile of liver obtained from liver-specific Me1-deficient mice challenged with high-fat diet

ABSTRACT: Gene expression profile of liver obtained from liver-specific Me1-deficient mice challenged with high-fat diet

PROVIDER: PRJNA1128104 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR29547810_1.fastq.gz	Fastqsanger.gz
	SRR29547810_2.fastq.gz	Fastqsanger.gz
	SRR29547811_1.fastq.gz	Fastqsanger.gz
	SRR29547811_2.fastq.gz	Fastqsanger.gz
	SRR29547812_1.fastq.gz	Fastqsanger.gz

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Gene expression profile of liver obtained from liver-specific Me1-deficient mice challenged with high-fat diet

Project description:Nonalcoholic fatty liver disease (NAFLD) has grown from a relatively unknown disease to the leading chronic liver disease globally. Malic enzyme 1 (ME1) is a cytosolic NADP+-dependent enzyme involved in the oxidative decarboxylation of malate to pyruvate while concomitantly generating nicotinamide adenine dinucleotide phosphate (NADPH) from NADP+. Previous genome-wide association studies have identified ME1 as a susceptibility gene for obesity and diabetes. This analysis was performed to understand the transcriptomic changes associated with hepatic Me1 loss in male mice challenged with high-fat diet.

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mRNA expression in liver of adult F2 female rats born to F0-fathers fed a chow or high-fat diet

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Project description:Global liver gene expression in mouse treated with either chow diet or high-fat diet was compared. Results provide insight into mechanisms underlying effects of high-fat diet on gene expression in mouse liver.

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