Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression analysis in C28/I2 cells: Comparison of OENC, DPP4 Overexpression, and DPP4 Overexpression with 4,5-Dicaffeoylquinic Acid Treatment Using RNA-Seq

ABSTRACT: Gene expression analysis in C28/I2 cells: Comparison of OENC, DPP4 Overexpression, and DPP4 Overexpression with 4,5-Dicaffeoylquinic Acid Treatment Using RNA-Seq

PROVIDER: PRJNA1141939 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR30039055_1.fastq.gz	Fastqsanger.gz
	SRR30039055_2.fastq.gz	Fastqsanger.gz
	SRR30039056_1.fastq.gz	Fastqsanger.gz
	SRR30039056_2.fastq.gz	Fastqsanger.gz
	SRR30039057_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Gene expression analysis in C28/I2 cells: Comparison of OENC, DPP4 Overexpression, and DPP4 Overexpression with 4,5-Dicaffeoylquinic Acid Treatment Using RNA-Seq

Project description:To examine the effects of DPP4 overexpression and its modulation by 4,5-Dicaffeoylquinic acid on chondrocytes, we established C28/I2 cell lines with DPP4 overexpression (DPP4OE), control empty vector (OENC), and DPP4OE treated with 4,5-Dicaffeoylquinic acid. Gene expression profiling analysis was performed using RNA sequencing (RNA-seq) with biological replicates to investigate the global transcriptomic changes associated with these conditions.

2025-02-19 | GSE273447 | GEO

Effect of Overexpression of DPP4 on Gene Expression in C28/I2 Chondrocyte Cells

Project description:We report here the overexpression of DPP4 in C28/I2 chondrocyte cells to investigate the changes induced by elevated levels of this gene. DPP4 is known as a marker of cellular senescence, yet its regulatory mechanisms remain unclear. In this study, we utilized the C28/I2 cell line to overexpress DPP4 and analyzed the resultant effects on gene expression and cellular behavior. Our findings reveal that DPP4 overexpression influences several pathways associated with chondrocyte function and senescence. Specifically, we observed alterations in pathways related to extracellular matrix organization, inflammatory response, and cellular aging. These results suggest that DPP4 plays a significant role in the modulation of chondrocyte senescence and may provide new insights into the mechanisms of cellular aging. Taken together, our data provide a molecular framework for understanding how DPP4 overexpression impacts chondrocyte physiology and offers potential targets for therapeutic intervention in age-related cartilage diseases.

2025-02-19 | GSE273261 | GEO

Effects of piR_019914 on gene expression in C28/I2 cells

Project description:In order to study the role of piR_019914 in C28/I2 cells, we established piR_019914_mimics to overexpress piR_019914 in C28/I2 cells We then performed gene expression profiling analysis using data obtained from RNA-seq of piR_019914 overexpression C28/I2 cells and mimics_NC C28/I2 cells.

2023-03-27 | GSE227945 | GEO

Effect of Overexpression of DPP4 on Gene Expression in C28/I2 Chondrocyte Cells

Project description:Effect of Overexpression of DPP4 on Gene Expression in C28/I2 Chondrocyte Cells

| PRJNA1141116 | ENA

Gene expression of C28/I2 cells with FABP4

Project description:Gene expression of C28/I2 cells with FABP4

| PRJNA945356 | ENA

Effects of piR_019914 on gene expression in C28/I2 cells

Project description:Effects of piR_019914 on gene expression in C28/I2 cells

| PRJNA947546 | ENA

Gene expression of C28/I2 cells in monolayer and spheroid culture

Project description:Gene expression of C28/I2 cells in monolayer and spheroid culture

| PRJNA931934 | ENA

Gene expression of C28/I2 cells with SDF-1 and natural products treatment

Project description:Gene expression of C28/I2 cells with SDF-1 and natural products treatment

| PRJNA812881 | ENA

Identification of C9orf72 as a potential target of osteoarthritis via STING/NF-κB axis by integrating bioinformatics and experiments

Project description:RNA-sequence analysis demonstrated ECM degradation and inflammation activation in C28/I2 cells with C9orf72 knockdown

2024-05-01 | GSE234255 | GEO

Gene expression of C28/I2 cells with FABP4

Project description:FABP4 has been reported to trigger ADAMTS4 overexpression in chondrocytes. Here we described the transcriptional changes of FABP4-treatment.

2023-06-22 | GSE227483 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data