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Transcriptomic of ileocecal junction of DBA/1 mice with spontaneous arthritis (SpAD)

ABSTRACT: Transcriptomic of ileocecal junction of DBA/1 mice with spontaneous arthritis (SpAD)

PROVIDER: PRJNA1166228 | ENA |

REPOSITORIES: ENA

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Transcriptomic of ileocecal junction of DBA/1 mice with spontaneous arthritis (SpAD)

Project description:The spontaneous arthritis (SpAD) model in the DBA/1 mouse strain resembles the Spondyloarthritis human disease, including the intestinal inflammation characterized by loss of the integrity of the epithelial barrier and increased permeability. The transcriptome characteristics in this mouse model's gut are very scarce. Transcriptome analysis was performed using DNA microarrays of ileocolic junction of DBA/1 strain mice with spontaneous arthritis (SpAD).

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Differential gene expression in the knee of DBA/1 mice with spontaneous arthritis (SpAD) compared to healthy BALB/c mice

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Differential gene expression in the knee of DBA/1 mice with spontaneous arthritis (SpAD) compared to healthy BALB/c mice

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Transcription profiling of mouse F2 intercross mice generated from arthritis-prone BALB/c and arthritis-resistant DBA/1 mice deficient for interleukin 1 receptor antagonist (Il1rn)

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profiling of midbrain from arthritic DBA/1 mice vs. control DBA/1 mice

Project description:The main function of the nervous system is to maintain homeostasis by sensing and reacting to signals that reach a certain threshold. For example, the brain can sense immune peripheral events through soluble compounds or the vagus nerve and can react through activation of the hypothalamus-pituitary-adrenal axis, resulting in the modulation of an ongoing immune response. Using microarrays we studied the gene expression profile of the midbrain in DBA/1 mice strain that developed collagen induced-arthritis vs control mice. Keywords: gene expression profile of the midbrain in response to induction of arthritis

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profiling of hypothalamus from arthritic DBA/1 mice vs. control DBA/1 mice

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profiling of prefrontal cortex from arthritic DBA/1 mice vs. control DBA/1 mice

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