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Exploring the genetic changes caused by vaccine treatment on MC38 tumor tissue

ABSTRACT: Exploring the genetic changes caused by vaccine treatment on MC38 tumor tissue

PROVIDER: PRJNA1173102 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR30997354_1.fastq.gz	Fastqsanger.gz
	SRR30997354_2.fastq.gz	Fastqsanger.gz
	SRR30997355_1.fastq.gz	Fastqsanger.gz
	SRR30997355_2.fastq.gz	Fastqsanger.gz
	SRR30997356_1.fastq.gz	Fastqsanger.gz

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Exploring the genetic changes caused by vaccine treatment on MC38 tumor tissue

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Bulk RNA-Seq analysis of MC38 colon carcinoma cells and MC38 Bap1-knockout cells in vitro

Project description:In order to find out which genes Bap1 regulates to affect the anti-tumor immune response in MC38 colon carcinoma cell linewe knocked out the Bap1 gene in the MC38 cell line through CRISPR-Cas9 technology, RNA was directly isolated for RNA seq and were able to investigate gene expression.

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Project description:To assess the role of Bap1 genes in MC38 colon carcinoma cell linewe knocked out the Bap1 gene in the MC38 cell line through CRISPR-Cas9 technology, MC38-Bap1-Wildtype and MC38-Bap1-Knockout tumor cells expressing BFP fluorescent protein were injected into Rag2-deficient mice subcutaneously. On the 10th day of tumor growth, BFP positive tumor cells were isolated and sorted by flow Cytometer. Bulk RNA-seq was performed on MC38-Bap1-Wildtype and MC38-Bap1-Knockout tumor cells for different gene signatures.

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Photoconversion of MC38

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Adenoviral Vectored Neoantigen Vaccine Augments Hyperexpanded CD8+ T Cell Control of Tumor Challenge in Mice

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