Drosophila melanogaster
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA119047 | ENA |
REPOSITORIES: ENA
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Project description:Bacterial and fungal infections induce a potent immune response in Drosophila melanogaster, but it is unclear whether viral infections induce a similar immune response. Using microarrays, we examined the changes in gene expression in Drosophila that occur in response to infection with the sigma virus, a negative-stranded RNA virus (Rhabdoviridae) that occurs in wild populations of D. melanogaster. We detected many changes in gene expression in infected flies, but found no evidence for the activation of the Toll, IMD or Jak-STAT pathways, which control immune responses against other pathogens. We identified a number of functional categories of genes, including serine proteases, ribosomal proteins and chorion proteins that were overrepresented among the differentially expressed genes. We also found that the sigma virus alters the expression of many more genes in males than in females. In contrast to previous results, our data suggest that either Drosophila do not mount an immune response against the sigma virus, or that the immune response is not controlled by known immune pathways. The genes which we identified as differentially expressed after infection are promising candidates for controlling the host’s response to the sigma virus.
2009-09-11 | GSE17377 | GEO
Project description:<p>Viral studies of Drosophila melanogaster typically involve virus injection with a small needle, causing post-injury a wounding/wound healing response, in addition to the effects of viral infection. However, the metabolic response to the needle injury is understudied, and many viral investigations neglect potential effects of this response. Furthermore, the wMel strain of the endosymbiont bacterium Wolbachia pipientis provides anti-viral protection in Drosophila. Here we used NMR-based metabolomics to characterise the acute wounding response in Drosophila and the relationship between wound healing and the Wolbachia strain wMel. The most notable response to wounding was found on the initial day of injury and lessened with time in both uninfected and Wolbachia infected flies. Metabolic changes in injured flies revealed evidence of inflammation, Warburg-like metabolism and the melanisation immune response as a response to wounding. In addition, at five days post injury Wolbachia infected injured flies were metabolically more similar to the uninjured flies than uninfected injured flies were at the same time point, indicating a positive interaction between Wolbachia infection and wound healing. This study is the first metabolomic characterisation of the wound response in Drosophila and its findings are crucial to the metabolic interpretation of viral experiments in Drosophila in both past and future studies.</p>
2025-11-18 | MTBLS13248 | MetaboLights
Project description:Transcriptional response of Drosophila S2 cells in response the Drosophila C Virus infection (DCV)
| PRJNA246453 | ENA
Project description:Transcriptional Response to Alcohol Exposure in Drosophila melanogaster
| PRJNA96289 | ENA
Project description:Drosophila melanogaster response to trypanosomatid infection
| PRJNA277742 | ENA
Project description:Transcriptional response to MnSOD over-expression in Drosophila melanogaster
| PRJNA98161 | ENA
Project description:Drosophila melanogaster Infection-regulated Transcriptome
| PRJNA348190 | ENA
Project description:Transcriptional response of Drosophila cells to FHV infection (infection experiment)
| PRJNA122967 | ENA
Project description:Reproductive status alters transcriptomic response to infection in female Drosophila melanogaster
| PRJNA193432 | ENA
Project description:Virus-derived siRNAs produced by Drosophila melanogaster
| PRJNA183973 | ENA