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Ultrasound-activated piezoelectric nanostickers for neural stem cell therapy of traumatic brain injury therapy

ABSTRACT: Ultrasound-activated piezoelectric nanostickers for neural stem cell therapy of traumatic brain injury therapy

PROVIDER: PRJNA1203906 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR31843712_1.fastq.gz	Fastqsanger.gz
	SRR31843712_2.fastq.gz	Fastqsanger.gz
	SRR31843713_1.fastq.gz	Fastqsanger.gz
	SRR31843713_2.fastq.gz	Fastqsanger.gz
	SRR31843714_1.fastq.gz	Fastqsanger.gz

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Ultrasound-activated piezoelectric nanostickers for neural stem cell therapy of traumatic brain injury therapy

Project description:Piezoelectric stimulation can promote neuronal differentiation of neural stem cells. Here we report a piezoelectric nanostickers that activate voltage-gated calcium channels (VGCC) on the surface of neural stem cells under ultrasound, inducing calcium ion influx.The influx of calcium ions leads to the upregulation of CaMKⅡ expression and phosphorylation, which initiates downstream signal transduction pathways in the process of neurogenesis. Phosphorylated CaMKⅡ (P-CaMKⅡ) enters the nucleus, where it facilities the phosphorylation of CREB. The phosphorylation of CREB enhances the expression of target gene, BDNF, ultimately leading to the completion of neurogenesis.

2025-01-13 | GSE285483 | GEO

Transcriptomic response of in vitro potato (Solanum tuberosum L.) to piezoelectric ultrasound

Project description:As part of a wider project to assess the impact of ultrasound on in vitro plant growth, this paper aimed to determine whether the application of piezoelectric ultrasound (PE-US) would induce changes to the transcriptome of in vitro potato (Solanum tuberosum L.). After exposing explants (single-node segments with a single leaf) to PE-US (35 kHz; 70 W) for 20 min, the effect of this stressor was determined at 0 h, 24 h, 48 h, 1 w and 4 w to assess the possible immediate and residual effects of PE-US on the potato transcriptome.

2020-03-03 | GSE135294 | GEO

3D-Printed GelMA/Hydroxyapatite/Barium Titanate Piezoelectric Hydrogels for Bone Tissue Engineering

Project description:Bone defect repair remains a major clinical challenge. This study presents a novel strategy using a 3D-printed piezoelectric hydrogel scaffold—composed of gelatin methacrylate (GelMA), hydroxyapatite (HA), and barium titanate (BTO)—for functional bone tissue engineering. The GelMA/HA/BTO (GelHABT) scaffold exhibited a well-defined porous structure, enhanced mechanical stability, and, crucially, reliable piezoelectric responsiveness. This key feature enables the material to convert external mechanical stimuli, such as low-intensity pulsed ultrasound (LIPUS), into endogenous electrical signals. In vitro, the scaffold promoted BMSCs adhesion, proliferation, and osteogenic differentiation, with performance significantly enhanced under LIPUS stimulation. Mechanistic insights revealed that the piezoelectric microenvironment remodeled the cellular miRNA expression profile, particularly up-regulating osteogenesis-related miR-29b-3p and activating the AMPK signaling pathway. Collectively, this ultrasound-responsive, gene-regulating scaffold represents a promising approach for treating bone defects by leveraging piezoelectricity to actively stimulate bone regeneration.

2026-01-28 | GSE317440 | GEO

Transcriptomic response of in vitro potato (Solanum tuberosum L.) to piezoelectric ultrasound

Project description:Transcriptomic response of in vitro potato (Solanum tuberosum L.) to piezoelectric ultrasound

| PRJNA558262 | ENA

Collagen-Enhanced Piezoelectric PLLA/ZnO Microfiber Barrier Membranes for Superior Bone Regeneration

Project description:Repairing large bone defects remains a significant clinical challenge. This study explores the development of collagen-enhanced piezoelectric microfiber barrier membranes (PLLA/ZnO@COL) for bone regeneration. The membranes' physicochemical properties, especially their piezoelectric characteristics, significantly influenced cellular behavior. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) confirmed the uniform dispersion of ZnO nanoparticles within the PLLA matrix, essential for optimal piezoelectric performance. The inclusion of collagen layers enhanced the electrical properties, cytocompatibility and osteogenic activity of the membranes. In vitro analyses, including bioinformatics, revealed that PLLA/ZnO@COL membranes upregulated key osteogenic pathways such as PI3K-AKT, MAPK, and Ras, thereby enhancing osteoblast proliferation, migration, and differentiation. Low-intensity pulsed ultrasound (LIPUS) stimulation further amplified these effects, indicating a synergistic role in enhancing osteoblast functions. In vivo studies using a rat mandibular bone defect model demonstrated that PLLA/ZnO@COL membranes, with the collagen layer facing the defect, significantly fostered new bone formation compared to control groups. Micro-CT analysis at 6 and 12weeks post-implantation showed higher bone mineral density, volume, and trabecular number in the PLLA/ZnO@COL group, indicating greater osteogenic activity. In conclusion, PLLA/ZnO@COL membranes, in conjunction with LIPUS, effectively enhance osteoblast functions and induce bone regeneration, showing potential as innovative barrier membranes in bone tissue engineering. The combination of piezoelectric properties, collagen enhancement, and LIPUS stimulation presents a novel approach to improving bone healing outcomes.

2026-02-28 | GSE289010 | GEO

Synergistic Effect of Ultrasound and Wirelessly Powered Electrical Stimulation on Piezoelectric Membranes for Enhanced Osteogenesis by Immunomodulation of Macrophage Polarization

Project description:Effect of Low-intensity pulsed ultrasound (LIPUS) assisted BT/MWCNTs/Col (BMC) membrane on gene expression during immune response of macrophages (Raw 264.7).

2023-07-31 | GSE236912 | GEO

Synergistic Effect of Ultrasound and Wirelessly Powered Electrical Stimulation on Piezoelectric Membranes for Enhanced Osteogenesis by Immunomodulation of Macrophage Polarization

Project description:Synergistic Effect of Ultrasound and Wirelessly Powered Electrical Stimulation on Piezoelectric Membranes for Enhanced Osteogenesis by Immunomodulation of Macrophage Polarization

| PRJNA993117 | ENA

Transcriptomic alterations induced by low-intensity ultrasound (LIUS) in OSCC.

Project description:Ultrasound therapy has emerged as a promising, non-invasive modality for cancer treatment, although its underlying mechanisms remain incompletely understood. Immunoblotting analysis revealed that low-intensity ultrasound (LIUS) alters global levels of histone modifications, including monoubiquitinated H2B (H2Bub1), H3K4me3, and H3K27me3, in oral squamous cell carcinoma (OSCC) OC3 cells. Given the pivotal role of histone marks in transcriptional regulation, we further investigated the effect of LIUS on transcriptional control in OC3 cells.

2026-02-20 | GSE299007 | GEO

A Programmable Liquid Ultrasound Transduer

Project description:Conventional ultrasound energy harvesters are solid with an acoustic impedance up to ~37 MRayl, which is about 20 times higher than that of biological tissues (1.63 MRayl). This impedance mismatch largely undermines the energy conversion efficiency and the spatial-access freedom for in vivo ultrasound energy harvester implantation. Here, to the best of our knowledge, we for the first time report a liquid ultrasound energy harvester with an ultralow acoustic impedance of ~1.66 MRayl, which shows near-zero impedance mismatch with biological tissues. Based on a coupling of magneto-viscoelasticity and magnetic induction, the liquid ultrasound energy harvester can deliver an unprecedentedly high-power density of ~21.63 mW cm-2 at a lower incident spatial peak temporal peak ultrasound intensity of ~1.36 W cm-2. Furthermore, it is programmable, deformable and can be adaptive to the dynamically evolving biological tissue surfaces via arbitrary dimensional architecture design. The liquid ultrasound energy harvester provides a seamless interface with biological tissues and is expected to revolutionize the current ultrasound technology.

2026-03-01 | GSE313669 | GEO

Ultrasound-Activated Piezoelectric Nanoparticles Inhibit Proliferation of Breast Cancer Cells.

Project description:A nanotechnology-based approach for the inhibition of breast cancer cell proliferation is proposed. The innovative solution consists in a platform based on biocompatible piezoelectric nanoparticles able to target and remotely stimulate HER2-positive breast cancer cells. The anti-proliferative effects of the ultrasound-driven piezoelectric nanoparticle-assisted stimulation significantly reduced the proliferation by inducing the cell cycle arrest. Similarly to a low-intensity alternating electric field, chronic piezoelectric stimulation resulted able to inhibit cancer cell proliferation by upregulating the expression of the gene encoding Kir3.2 inward rectifier potassium channels, by interfering on Ca2+ homeostasis, and by affecting the organization of mitotic spindles during mitosis. The proposed platform, even if specific for HER2-positive cells, shows huge potential and versatility for the treatment of different type of cancers.

| S-EPMC5908835 | biostudies-literature

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