Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ScRNA-seq data of spleen immune cells from Vehicle- and Glutoborin-treated mice

ABSTRACT: scRNA-seq data of spleen immune cells from Vehicle- and Glutoborin-treated mice

PROVIDER: PRJNA1226950 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR32454994.fastq.gz	Fastqsanger.gz
	SRR32454995.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

scRNA-seq data of spleen immune cells from Vehicle- and Glutoborin-treated mice

Project description:To determine whether Glutoborin exerts its immunomodulatory effects by disrupting interactions between MZMs and MZBs, we performed scRNA-seq to analyze the immune microenvironment of spleens from Pb-infected mice treated with Vehicle or Glutoborin.

2025-02-23 | GSE290269 | GEO

scRNA-seq data of spleen immune cells from Pb-infection and Un-infection mice

Project description:To explore the immune microenvironment of spleen in the state of Plasmodium infection, we employed single-cell RNA sequencing (scRNA-seq)..

2025-02-26 | GSE290172 | GEO

Project description:Significant differences in gene expression were observed for 5-Azacytidine treated leukemic mice compared to vehicle treated mice during hematologic remission in both spleen and blood samples

2025-05-22 | GSE283410 | GEO

scRNA-seq data of spleen immune cells from Pb-infection and Un-infection mice

Project description:scRNA-seq data of spleen immune cells from Pb-infection and Un-infection mice

| PRJNA1226515 | ENA

scRNA-seq of rodent malaria parasites (P. berghei) and their host cells in spleen, bone marrow and blood

Project description:The malaria parasite Plasmodium replicates and differentiates in red blood cells of its host. The erythropoietic niches (spleen and bone marrow) are important but poorly understood reservoirs of asexual replication and sexual development. We aimed to understand how the parasite adapts to its host organ and a host cell level. For this, we performed single-cell RNA-seq (scRNA-seq) analysis on host and parasite cells derived from spleen, blood and bone marrow. Organs were harvested from two infected and one uninfected mice and parasite cells were enriched to about 50% by flow sorting (infected samples only). To identify host cells by surface expression (CITE-seq), cells were stained with barcoded antibodies targeting CD44 and CD71. Droplet-based scRNA-seq of these samples was performed using 10X genomics technology and cDNA was sequenced on Illumina.

2021-11-30 | E-MTAB-10800 | biostudies-arrayexpress

Single-cell RNA sequencing of bone marrow cells and spleen isolated from mice after sham surgery or myocardial infarction, followed by treatments (vehicle/4-oxo-RA)

Project description:Study of the impact of 4-oxo-RA on LSK (bone marrow and spleen) cell characteristics post-myocardial infarction in C57BL/6J mice. Myocardial infarction was induced in female C57BL/6J mice (aged 6 to approximately 12 weeks) through LAD occlusion. Post-surgery, mice were intraperitoneally injected with 30 mg/kg 4-oxo-RA (MI+4-oxo-RA) or the equivalent DMSO in PBS (MI+vehicle) on the 1st and 2nd days after MI. Three days post-MI, mice were euthanized. ScRNA-seq was performed on 25k LSK cells (Lin-, Sca1+, c-Kit+) that were facs sorted.

2025-02-06 | E-MTAB-13510 | biostudies-arrayexpress

Project description:Immune-related gene expression data of whole blood and spleen from immuno-competent mice implanted with C1498 leukemia cells (AML model) and treated with 5-Azacytidine or Vehicle

| PRJNA1193599 | ENA

Mouse spleen LC-MSMS: effects of age and immune challenge

Project description:Ageing is characterized by the progressive lowering of the acute innate immune response and the progressive up-regulation of low-grade inflammation (i.e. inflammaging). At the cellular level, telomeres are considered as a mark of ageing as their length is progressively shortened. However, the links between telomeres and innate immune ageing remain undefined. Using a proteomic approach conducted on laboratory mice, we tested whether the experimental triggering of an acute innate response is deleterious for telomere maintenance, and whether this is dependent of age. To do so, we challenged young and old mice using bacterial lipopolysaccharide (LPS) and measured individuals’ end-points of telomere length and proteomic profiles in spleen tissue.

2019-03-12 | PXD009005 | Pride

MSX Spleen DIA and DDA Proteomics

Project description:This project evaluates the immune regulating properties of maple syrup extract in spleen samples utilizing an LPS induced peritonitis mouse model.

2023-11-03 | MSV000093293 | MassIVE

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL

Project description:Two mice in which luciferase-positive LOUCY ETP-ALL cells were xenografted were treated with either vehicle or ABT-199 (50 mg/kg) for 11 days. Afterwards, single cells suspensions were made from bone marrow and spleen of both mice for 10x Genomics scRNA-seq. Following quality control, a total of 13,681 spleen cells and 11,442 bone marrow cells of the control mouse and 15,955 spleen cells and 9,443 bone marrow cells of the ABT 199 treated mouse were processed for further analysis. Our data show that ABT-199 triggers transcriptional changes in T-cell differentiation genes in leukemic cells obtained from the spleen microenvironment. These results are in line with our previous findings that mature typical T-ALL are resistant to ABT-199.

2021-03-10 | GSE168594 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data