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Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors

ABSTRACT: Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors

PROVIDER: PRJNA1248425 | ENA |

REPOSITORIES: ENA

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Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors II

Project description:Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors II

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Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors

Project description:Committed progenitors with innate lymphoid cell (ILC) developmental potential are present in the fetus and bone marrow (BM). However, how fetal and BM hematopoiesis temporally and spatially contributes to ILC pools remains unclear. Here, we elucidated the distinct origins and developmental pathways of extramedullary and intramedullary ILCs during ontogeny. ILC-restricted hematopoiesis is initiated in the fetal liver (FL) and then FL-derived PD-1+ ILC progenitors (ILCPs) seed fetal lung and intestine. Organ niches determine the commitment of ILCPs to downstream precursors, including bipotent ILC1-ILC3 precursors (ILC1/3Ps) that are preferentially residing in the liver and intestine and ILC2 precursors (ILC2Ps) that show predominance in the lung. These precursors persist in adulthood and contribute to local ILC pools via BM-independent manner. In contrast, intramedullary ILC2Ps and ILC2s rely on BM hematopoiesis. Thus, our study highlights extramedullary and intramedullary ILCs with different origins, providing a comprehensive framework for developmental dynamics of ILCs.

2025-07-14 | GSE294130 | GEO

Innate Lymphoid Cells Originate from Fetal Liver-Derived Tissue-Resident Progenitors II

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RNA-seq of mouse common lymphoid progenitors, innate lymphoid cell progenitors and NK cell progenitors

Project description:Natural Killer (NK) cells at different developmental stages (common lymphoid progenitor (CLP), innate lymphoid cell progenitors (ILCP), and refined NK progenitor (NKP)) were collected from Vav1+iCre FOXO1,3flox/flox mice (C57BL/6 background). Total RNA was harvested and sequenced with a strand-specific paired-end RNA-seq protocol.

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Project description:Skin-resident innate lymphoid cells converge on a pathogenic effector state

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RNA-seq of mouse common lymphoid progenitors, innate lymphoid cell progenitors and NK cell progenitors

Project description:RNA-seq of mouse common lymphoid progenitors, innate lymphoid cell progenitors and NK cell progenitors

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Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

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Project description:Regulatory innate lymphoid cells control innate intestinal inflammation

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Development and differentiation of early innate lymphoid progenitors

Project description:Early innate lymphoid progenitors (EILP) have recently been identified in the mouse adult bone marrow as a multipotential progenitor population committed to ILC lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor-successor relationships between EILP, IL-7R+ common lymphoid progenitors (ALP), and ILC precursors (ILCp). Bioinformatic, phenotypical, functional, and genetic approaches collectively establish EILP as an intermediate progenitor between ALP and ILCp. Our work additionally provides new candidate regulators of ILC development and clearly defines the stage of requirement of transcription factors key for early ILC development.

2017-11-15 | GSE81530 | GEO

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

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