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MTBP Cut&Run of FACS sorted cell cycle populations in HCT116 cells

ABSTRACT: MTBP Cut&Run of FACS sorted cell cycle populations in HCT116 cells

PROVIDER: PRJNA1250943 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR33137170_1.fastq.gz	Fastqsanger.gz
	SRR33137170_2.fastq.gz	Fastqsanger.gz
	SRR33137171_1.fastq.gz	Fastqsanger.gz
	SRR33137171_2.fastq.gz	Fastqsanger.gz
	SRR33137172_1.fastq.gz	Fastqsanger.gz

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MTBP Cut&Run of FACS sorted cell cycle populations in HCT116 cells

Project description:The selection of replication origins plays a crucial role in eukaryotic DNA replication. However, the mechanisms of origin selection in humans are not yet well-defined. Recent work in yeast has shown that the recruitment of Sld3-Sld7 to origins during G1 is involved in origin selection. In humans, TICRR and MTBP are the orthologs of Sld3 and Sld7, respectively. In this study, we have mapped the genomic binding locations of MTBP in G1, early S, late S, and G2 populations of cells.

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Project description:The selection of replication origins plays a crucial role in eukaryotic DNA replication. However, the mechanisms of origin selection in humans are not yet well-defined. Recent work in yeast has shown that the recruitment of Sld3-Sld7 to origins during G1 is involved in origin selection. In humans, TICRR/TRESLIN and MTBP are the orthologs of Sld3 and Sld7, respectively. In this study, we have mapped the genomic binding locations of TICRR/TRESLIN and MTBP in asynchronous cells.

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Project description:The selection of replication origins plays a crucial role in eukaryotic DNA replication. However, the mechanisms of origin selection in humans are not yet well-defined. Recent work in yeast has shown that the recruitment of Sld3-Sld7 to origins during G1 is involved in origin selection. In humans, TICRR/TRESLIN and MTBP are the orthologs of Sld3 and Sld7, respectively. In this study, we have mapped the genomic binding locations of TICRR/TRESLIN and MTBP in a population of G1 synchronized cells.

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Project description:In this study, we have mapped the binding sites for the MTBP subunit of the Treslin-MTBP complex throughout the human genome by using the CUT&RUN method. Our results have indicated that MTBP associates reproducibly with several tens of thousands of sites in the genome. Many binding sites contain either G4 DNA or an AP-1 motif in a nucleosome-free region at transcription start sites (TSSs) or enhancers, respectively. In addition, this nucleosome-free region is adjacent to a nucleosome containing certain histone marks characteristic of open chromatin that have also been implicated in initiation. We also mapped early initiation zones with EdU-labeling (EdU-seq) and found that these initiation domains contain a large number of MTBP binding sites. Taken together, these findings indicate that Treslin-MTBP associates with multiple genomic signals to promote initiation of replication.

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