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Brown remodeling of white adipose tissue protects against abdominal aortic aneurysm via a novel batokine FSTL1 [CL316,243]

ABSTRACT: Brown remodeling of white adipose tissue protects against abdominal aortic aneurysm via a novel batokine FSTL1 [CL316,243]

PROVIDER: PRJNA1261016 | ENA |

REPOSITORIES: ENA

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Brown remodeling of white adipose tissue protects against abdominal aortic aneurysm via a novel batokine FSTL1

Project description:Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease without effective medical therapies. Emerging evidences have suggested a crosstalk between adipose tissue and vascular cells and brown adipose tissue is beneficial for cardiovascular health. Nevertheless, whether brown remodeling of white adipose tissue would protect against AAA remains unclear. Here we showed that patients with AAA had a decreased browning level of adipose tissue and induction of adipose tissue browning significantly reduced AAA incidence and attenuated AAA development in mice. Using LC-MS/MS and proteomic analysis, we further identified Follistatin-like 1 (FSTL1) as a novel vessel-protective adipokine secreted by browning adipocytes. Mechanistically, FSTL1 inhibited VSMC apoptosis through DIP2A/AKT signaling. Furthermore, we demonstrated that adipocyte-specific deficiency of FSTL1 abrogated the protective effect of browning induction. Moreover, supplementation of FSTL1 either systemically or patched into hydrogel placing around abdominal aorta markedly limited aortic dilation and AAA progression. Our data suggest a protective role of adipose tissue browning and a novel batokine FSTL1 in the development of AAA, which may represent a novel intervention strategy for AAA.

2025-09-06 | GSE296628 | GEO

Brown remodeling of white adipose tissue protects against abdominal aortic aneurysm via a novel batokine FSTL1 [CL316,243]

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Brown remodeling of white adipose tissue protects against abdominal aortic aneurysm via a novel batokine FSTL1

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Transcriptomic change related to abdominal aortic aneurysm pathogenesis

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abdominal aortic aneurysm (AAA) proteomics

Project description:An abdominal aortic aneurysm (AAA) is a pathological dilatation of the aortic wall and it is a life-threatening disease due to the risk of rupture. Currently, surgical intervention remains the only definitive treatment recommended for large or rapidly expanding aneurysms. No pharmacological therapy is currently available to prevent AAA progression, as no drug has been proven effective. Diabetes is a major risk factor for cardiovascular disease in general. However, many studies over the last decade show that type 2 diabetes patients have a lower incidence of AAA and a slower aneurysm growth rate, which has been correlated with metformin use. We performed a proteomics analysis on resected aortic tissue from controls, non-diabetic (ND) and diabetic (D) AAA patients.

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Project description:We have employed circRNA microarray expression profiling as a discovery platform to identify the dysregulated circRNAs in human abdominal aortic aneurysm.

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