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Brown remodeling of white adipose tissue protects against abdominal aortic aneurysm via a novel batokine FSTL1 [CL316,243]

ABSTRACT: Brown remodeling of white adipose tissue protects against abdominal aortic aneurysm via a novel batokine FSTL1 [CL316,243]

PROVIDER: PRJNA1261016 | ENA |

REPOSITORIES: ENA

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Brown remodeling of white adipose tissue protects against abdominal aortic aneurysm via a novel batokine FSTL1

Project description:Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease without effective medical therapies. Emerging evidences have suggested a crosstalk between adipose tissue and vascular cells and brown adipose tissue is beneficial for cardiovascular health. Nevertheless, whether brown remodeling of white adipose tissue would protect against AAA remains unclear. Here we showed that patients with AAA had a decreased browning level of adipose tissue and induction of adipose tissue browning significantly reduced AAA incidence and attenuated AAA development in mice. Using LC-MS/MS and proteomic analysis, we further identified Follistatin-like 1 (FSTL1) as a novel vessel-protective adipokine secreted by browning adipocytes. Mechanistically, FSTL1 inhibited VSMC apoptosis through DIP2A/AKT signaling. Furthermore, we demonstrated that adipocyte-specific deficiency of FSTL1 abrogated the protective effect of browning induction. Moreover, supplementation of FSTL1 either systemically or patched into hydrogel placing around abdominal aorta markedly limited aortic dilation and AAA progression. Our data suggest a protective role of adipose tissue browning and a novel batokine FSTL1 in the development of AAA, which may represent a novel intervention strategy for AAA.

2025-09-06 | GSE296628 | GEO

Brown remodeling of white adipose tissue protects against abdominal aortic aneurysm via a novel batokine FSTL1 [CL316,243]

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Plasma Proteomics from Subjects with Abdominal Aortic Aneurysm

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Brown remodeling of white adipose tissue protects against abdominal aortic aneurysm via a novel batokine FSTL1

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Olfr2 deficiency protects from abdominal aortic aneurysm

Project description:Olfactory receptor 2 is a G-protein coupled receptor expressed on vascular macrophages. Activation by its ligand octanal in conjuction with a toll like receptor 4 stimulus induces the NLRP3 inflammasome with subsequent IL-1alpha and IL-1beta release. In this study we aim to investigate the effects of genetic Olfr2 deficiency on the development of abdominal aortic aneurysm (AAA).

2025-12-09 | GSE288403 | GEO

Olfr2 deficiency protects from abdominal aortic aneurysm

Project description:Olfr2 deficiency protects from abdominal aortic aneurysm

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Difference analysis of microRNAs in abdominal aorta of ApoE-/- AngII-induced abdominal aortic aneurysm mices

Project description:Abdominal aortic aneurysm (AAA) is a vascular disease with high incidence at present.There is no effective drug treatment. MicroRNAs(miRNAs) play a regulatory role in the occurrence and development of AAA,and miRNA therapy is a promising treatment for AAA. The purpose of this study was to explore the differential expression of miRNAs in abdominal aorta of ApoE-/- AngII-induced abdominal aortic aneurysm mices. We used miRNA array to analyze miRNA differences in abdominal aorta between mices with ApoE-/- AngII-induced abdominal aortic aneurysm and ApoE-/-.

2025-10-29 | GSE280216 | GEO

Transcriptomic change related to abdominal aortic aneurysm pathogenesis

Project description:Angiotensin II (Ang II)-induced abdominal aortic aneurysm model was established in low-density lipoprotein receptor-deficient mice, and the gene expression profiles in abdominal aortic tissues exhibiting varying degrees of severity were analyzed.

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abdominal aortic aneurysm (AAA) proteomics

Project description:An abdominal aortic aneurysm (AAA) is a pathological dilatation of the aortic wall and it is a life-threatening disease due to the risk of rupture. Currently, surgical intervention remains the only definitive treatment recommended for large or rapidly expanding aneurysms. No pharmacological therapy is currently available to prevent AAA progression, as no drug has been proven effective. Diabetes is a major risk factor for cardiovascular disease in general. However, many studies over the last decade show that type 2 diabetes patients have a lower incidence of AAA and a slower aneurysm growth rate, which has been correlated with metformin use. We performed a proteomics analysis on resected aortic tissue from controls, non-diabetic (ND) and diabetic (D) AAA patients.

2025-09-29 | PXD067859 | Pride

RNA-sequencing of abdominal aortic aneurysm (AAA) and control abdominal aorta tissues

Project description:Abdominal aortic aneurysm (AAA) is a permanent segmental dilatation of the abdominal aorta, contributing to a high mortality once rupture. We performed RNA-sequencing analysis of abdominal aorta tissues from 14 participants, including seven patients with AAA and seven control individuals.

2023-12-07 | GSE183464 | GEO

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