Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dissecting the cell autonomous and non-autonomous effects of DNMT1 deletion in cortical somatostatinergic interneurons

ABSTRACT: Dissecting the cell autonomous and non-autonomous effects of DNMT1 deletion in cortical somatostatinergic interneurons

PROVIDER: PRJNA1268979 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR33732534_1.fastq.gz	Fastqsanger.gz
	SRR33732534_2.fastq.gz	Fastqsanger.gz
	SRR33732535_1.fastq.gz	Fastqsanger.gz
	SRR33732535_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 5

Similar Datasets

Dissecting the cell autonomous and non-autonomous effects of DNMT1 deletion in cortical somatostatinergic interneurons

Project description:The development of cortical circuits, made up of excitatory neurons and inhibitory interneurons, is a fine-tuned and vital process during brain development. Aberrations affecting the establishment of these circuits are implicated in several neuropsychiatric and neurological disorders. While excitatory neurons originate in cortical proliferative zones, inhibitory interneurons migrate from the basal telencephalon into the cortex. This migration is regulated by intrinsic genetic programs and extrinsic cues. Here, we aimed to identify the role of the DNA methyltransferase 1 (DNMT1) in controlling the expression of key genes implicated in the development and migration of post-mitotic somatostatin-positive interneurons as well as its impact on the rest of the cortical population.

2025-06-18 | GSE298336 | GEO

DOT1L deletion impairs the development of cortical Parvalbumin-expressing interneurons

Project description:Our group has reported that the histone methyltransferase DOT1L is necessary for proper cortical plate development and layer distribution of glutamatergic neurons, however, its specific role on cortical interneuron development has not yet been explored. Here, we demonstrate that DOT1L affects interneuron development in a cell-autonomous manner. Deletion of Dot1l in MGE-derived interneuron precursor cells results in an overall reduction and altered distribution of GABAergic interneurons in the cortical plate at postnatal day (P) 0. Furthermore, we observed an altered proportion of GABAergic interneurons in the cortex and striatum at P21 with a significant decrease in Parvalbumin (PVALB)-expressing interneurons. Altogether, our results indicate that reduced numbers of cortical interneurons upon DOT1L deletion results from altered postmitotic differentiation/maturation.

2023-08-01 | GSE221994 | GEO

Identifying the role of DNMT1 in gene expression regulation in somatostatinergic interneurons during embryonic corticogenesis [RNA-Seq]

Project description:The establishment of neuronal circuits, made up of excitatory neurons and inhibitory interneurons, is a fine-tuned process during corticogenesis and is pivotal for a functional brain. Developmental aberrations affecting these circuits are implicated in several neuropsychiatric disorders. While excitatory neurons originate in cortical proliferative zones, inhibitory interneurons migrate from the basal telencephalon into the cortex. This migration is regulated by intrinsic genetic programs and extrinsic cues. Here, we aimed to identify the role of the DNA methyltransferase 1 (DNMT1) in controlling the expression of key genes implicated in mouse cortical interneuron development and the migration of somatostatin-expressing interneurons within the developing cortex.

2025-06-18 | GSE276516 | GEO

Identifying the role of DNMT1 on methylation signatures in somatostatinergic interneurons during embryonic corticogenesis [EM-seq]

Project description:The establishment of neuronal circuits, made up of excitatory neurons and inhibitory interneurons, is an intricately regulated process during development and is vital for proper brain function. Its perturbations are increasingly implicated in several neuropsychiatric disorders. While excitatory neurons are born in proliferative zones of the cortex, cortical inhibitory interneurons are born in the basal telencephalon and migrate into the cortex. This process is regulated by intrinsic genetic programs as well as extrinsic cues. Here, we aimed to characterize the role of the DNA methyltransferase 1 (DNMT1) in controlling the methylation of key genes implicated in the development and the migration of somatostatin-expressing interneurons within the developing murine cortex.

2025-06-18 | GSE298865 | GEO

Dnmt1 deletion in Hmx3-positive POA-derived interneurons [MeDIP-seq]

Project description:The proliferative niches in the subpallium generate a rich cellular variety fated for diverse telencephalic regions. The embryonic preoptic area (POA) represents one of these domains giving rise to the pool of cortical GABAergic interneurons and glial cells, in addition to striatal and residual POA cells. The migration from sites of origin within the subpallium to the distant targets like the cerebral cortex, accomplished by the adoption and maintenance of a particular migratory morphology, is a critical step during interneuron development, which seems to be regulated partially via DNA methylation-dependent gene expression. To identify genes that are altered by DNA methylation mediated by DNMT1 in POA-derived Hmx3-positive interneurons, we used an Hmx3-Cre/tdTomato/Dnmt1loxP mouse model and FAC-sorted the basal telencephalon at E16. RNA and MeDIP sequencing were performed. MeDIP data are assigned here.

2021-03-09 | GSE146967 | GEO

Dnmt1 deletion in Hmx3-positive POA-derived interneurons [RNA-seq]

2021-03-09 | GSE146966 | GEO

Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice

Project description:Dnmt1 deletion in PV-positive cortical interneurons of 6 month and 18 month old mice

| PRJNA605736 | ENA

Developmental diversification of cortical inhibitory interneurons

Project description:Developmental diversification of cortical inhibitory interneurons

| PRJNA411832 | ENA

MYT1L genome-wide occupancy in human pluripotent stem cell-derived cortical interneurons

Project description:We have used our protocol for generating cortical interneurons from human pluripotent stem cells to study MYT1L genome-wide occupancy in human cortical interneurons.

2025-01-18 | GSE244185 | GEO

Rbfox1 mediates cell-type specific splicing in cortical interneurons

Project description:Cortical interneurons display a remarkable diversity in their morphology, physiological properties and connectivity. Elucidating the molecular determinants underlying this heterogeneity is essential for understanding interneuron development and function. We discovered that alternative splicing differentially regulates the integration of somatostatin- and parvalbumin-expressing interneurons into nascent cortical circuits through the cell-type specific tailoring of mRNAs. Specifically, we identified a role for the activity-dependent splicing regulator Rbfox1 in the development of cortical interneuron subtype specific efferent connectivity. Our work demonstrates that Rbfox1 mediates largely non-overlapping alternative splicing programs within two distinct but related classes of interneurons.

2018-10-12 | GSE119998 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data