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Genome reorganisation and transcriptional changes during activation of the human T-cell line Jurkat

ABSTRACT: Genome reorganisation and transcriptional changes during activation of the human T-cell line Jurkat

PROVIDER: PRJNA374975 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5261760.fastq.gz	Fastqsanger.gz
	SRR5261761.fastq.gz	Fastqsanger.gz
	SRR5261762.fastq.gz	Fastqsanger.gz
	SRR5261759.fastq.gz	Fastqsanger.gz

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The Transcriptome of over expressed SLAMF6 isoform-3 in activated Jurkat cell line

Project description:SLAMF6 is a homotypic receptor of the Ig-superfamily associated with progenitor exhausted T cells. In humans, SLAMF6 has three splice isoforms involving its V-domain.We KO isoform 1 of SLAMF6 in a Jurkat cell line and harvest this cell line RNA using Bulk-RNA-Seq after activation in 5 time points. Comparing the results to WT Jurkat cell line, we analyzed the transcriptional landscape and showed that after activation SLAMF6 isoform 3 is the prominent expressed isoform, and that the KO Jurkat cells have a stronger cytotoxic phenotype.

2020-11-05 | GSE160817 | GEO

Genome reorganisation and transcriptional changes during activation of the human T-cell line Jurkat

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-04-12 | GSE94972 | GEO

Changes in genetic transcription patterns in Jurkat cells treated with Tamoxifen

Project description:In this research, we use DNA microarray analysis to clarify the gene expression responses in Jurkat cells after Tamoxifen treatment. Jurkat cells are a dexamethasone-resistant cell line derived from a T-cell Acute Lymphoblastic Leukaemia sample in relapse

2019-09-02 | GSE122852 | GEO

AGO2 bound short RNAs in Jurkat cell line

Project description:AGO2 bound short RNAs in Jurkat cell line

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Effect of XPO1 Inhibition on Jurkat T Cell Activation

Project description:To assess the effects of small molecules SP100030 and Selinexor on Jurkat T cells activated by PMA/Ionomycin after 6 hours of activation and treatment

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Identification of LEDGF-responsive genes in Jurkat cells

Project description:The LEDGF transcript from the PSIP1 gene was knocked down in Jurkat cells using RNAi technology. The resulting Jurkat-derived cell line (Jurkat-siJK2) was compared to a control cell line (wild type Jurkat) using microarray analysis. Genes identified as being modulated by LEDGF were preferential targets of HIV integration. Keywords: effects of gene knockdown

2007-04-13 | GSE7508 | GEO

SIX6 knockdown in Jurkat-Cas9 T-ALL cell line

Project description:SIX6 knockdown in Jurkat-Cas9 T-ALL cell line

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Phosphoproteomics quantitative characterization in Jurkat E6.1 and Jurkat Gamma1.

Project description:Phosphorylation is a reversible post-translational modification, playing a vital role in protein function. In T cells, protein phosphorylation is the key mechanism regulating T cell receptor – driven signaling pathways. In order to gain insights into the phosphoproteome evolution of T cell activation, we performed a large-scale quantitative phosphoproteomics study of Jurkat E6.1 (wild type) and Jurkat gamma1 (Phospholipase gamma1 null) cell clones upon costimulation with anti-CD3 and anti-CD28 antibodies at times ranging from 15 min to as long as 120 min. In total, we identified 5585 phosphopeptides belonging to 2008 phosphoproteins from both cell clones. We detected 130 and 114 novel phosphopeptides in Jurkat E6.1 and Jurkat gamma1 clones, respectively. A significantly lower number of proteins containing regulated phosphorylation sites were identified in Jurkat gamma1 in comparison to Jurkat E6.1, reflecting the vital role of Phospholipase gamma1 in T cell signaling. Several new phosphorylation sites from lymphocyte-specific protein tyrosine kinase (LCK) were identified. Of these, Serine-121 showed significant changes in JE6.1 while only small changes in the Jgamma1 clone.

2015-11-10 | PXD002871 | Pride

Effect of XPO1 Inhibition on Jurkat T Cell Activation

Project description:Effect of XPO1 Inhibition on Jurkat T Cell Activation

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role of miR-146a on Jurkat T cells

Project description:screenning the differentially expressed genes of Jurkat-FF3, Jurkat-miR146a, Jurkat-miR146a-sponge cell lines. To investigate the role of miR-146a on Jurkat T cells, we screened the differentially expressed genes of Jurkat-FF3 (as control), Jurkat-miR146a (as miR-146a overexpression cell line), Jurkat-miR146a-sponge (as miR-146a knock down cell line).

2010-04-03 | E-GEOD-21132 | biostudies-arrayexpress

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