Project description:Stroma secretes complex regulatory signals, including reactive oxygen species, that are involved in mediating cancer development. Ablation of PPARB expression in fibroblastic cells results in modulation of oxidative stress signals that lead By means of gene expression analysis, we seek to identify key gene expression changes in tumor epithelial cells between FSPCre-PPARB -/- and PPARB flox/flox mice.
Project description:Stroma secretes a multitude of regulatory signals that are involved in mediating intestinal development. Ablation of PPARB expression in fibroblastic cells results in modulation of oxidative stress signals that lead to altered intestinal morphology and gene expression profiles Through gene chip expression profiling, we seek to identify key changes in intestinal mucosal gene expression profiling between FSPCre-PPARB flox/flox and PPARB flox/flox mice.
Project description:Comparative expression data between the epidermis and dermis of wild-type (Pparb/d^fl/fl) and fibroblast-selective knockout Pparb/d (FSPCre-Pparb/d^fl/fl) mice
Project description:We collected whole genome testis expression data from hybrid zone mice. We integrated GWAS mapping of testis expression traits and low testis weight to gain insight into the genetic basis of hybrid male sterility.
