Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Male Germ Cells Support Long-Term Propagation of Zika Virus

ABSTRACT: Male Germ Cells Support Long-Term Propagation of Zika Virus

PROVIDER: PRJNA450377 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7009050.fastq.gz	Fastqsanger.gz
	SRR7009051.fastq.gz	Fastqsanger.gz
	SRR7009052.fastq.gz	Fastqsanger.gz
	SRR7009047.fastq.gz	Fastqsanger.gz
	SRR7009048.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Male Germ Cells Support Long-Term Propagation of Zika Virus

Project description:Evidence of male-to-female sexual transmission of Zika virus (ZIKV) and viral RNA in semen and sperm months after infection support a potential role for testicular cells in ZIKV propagation. Here, we demonstrate that germ cells (GC) are most susceptible to ZIKV. We find that only GC infected by ZIKV, but not those infected by dengue fever (DENV) and yellow fever virus (YFV), produce high levels of infectious virus. This observation coincides with decreased expression of interferon-stimulated gene Ifi44l in ZIKV-infected GC and over-expression of Ifi44l results in reduced ZIKV production. Using primary human testicular tissue, we demonstrate that human GC are also permissive for ZIKV infection and production. Finally, we identify berberine chloride as a potent inhibitor of ZIKV infection in both murine and human testes. Together, these studies identify a potential cellular source for propagation of ZIKV in testes and a candidate drug for preventing sexual transmission of ZIKV.

2018-06-06 | GSE113177 | GEO

Male germ cells support long-term propagation of Zika virus.

Project description:Evidence of male-to-female sexual transmission of Zika virus (ZIKV) and viral RNA in semen and sperm months after infection supports a potential role for testicular cells in ZIKV propagation. Here, we demonstrate that germ cells (GCs) are most susceptible to ZIKV. We found that only GCs infected by ZIKV, but not those infected by dengue virus and yellow fever virus, produce high levels of infectious virus. This observation coincides with decreased expression of interferon-stimulated gene Ifi44l in ZIKV-infected GCs, and overexpression of Ifi44l results in reduced ZIKV production. Using primary human testicular tissue, we demonstrate that human GCs are also permissive for ZIKV infection and production. Finally, we identified berberine chloride as a potent inhibitor of ZIKV infection in both murine and human testes. Together, these studies identify a potential cellular source for propagation of ZIKV in testes and a candidate drug for preventing sexual transmission of ZIKV.

| S-EPMC5974187 | biostudies-literature

AMFc propagation cycles

Project description:AMFc propagation cycles

| PRJEB71400 | ENA

Microarray analysis of MRC-5 cells infected with Zika virus strains

Project description:To better understand the critical drivers of Zika virus pathogenicity, we used microarray analysis to evaluate the host responses triggered by Zika virus infection in MRC-5 cells.

2021-03-23 | E-MTAB-10292 | biostudies-arrayexpress

RNA-seq transcript and gene data on zika exposed and zika naïve samples

Project description:RNA-seq count data at 3 timepoints was generated for Zika-exposed and Zika-naïve individuals in order to assess associated signatures

2019-04-17 | GSE129882 | GEO

Zika genome

Project description:Zika genome

| PRJEB34688 | ENA

Transcriptomics in Zika virus-infected human brain organoids

Project description:PolyA+ RNA sequencing of Zika virus-infected human brain organoids at 5 days post-infection.

2017-04-03 | E-MTAB-4811 | biostudies-arrayexpress

CRISPR screen for the identification of host factors for ZIKA virus infection

Project description:To search for host factors regulating Zika virus infection, we performed a genome-wide loss-of-function CRISPR/Cas9 screen in haploid human ESCs. The regulators were identified by the quantification of enrichment of their mutant clones within a pooled loss-of-function library upon Zika virus infection.

2023-05-31 | E-MTAB-11945 | biostudies-arrayexpress

zika

Project description:nghien cuu ve virut zika

| PRJEB13387 | ENA

RNA interactome capture analysis of mouse male germ cells

Project description:Mass spectrometry data of RNA interactome capture (RIC) assay for STA-PUT purified mouse primary male germ cells, including spermatogonia (SG), pachytene spermatocyte (pSC) and round spermatid (rST)

2025-10-29 | PXD043074 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data