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Anti-aging effects of Vicatia thibetica de Boiss root extract on Caenorhabditis elegans and doxorubicin-induced mice via promoting collagen and stress resistance

ABSTRACT: Anti-aging effects of Vicatia thibetica de Boiss root extract on Caenorhabditis elegans and doxorubicin-induced mice via promoting collagen and stress resistance

PROVIDER: PRJNA706907 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13863231_1.fastq.gz	Fastqsanger.gz
	SRR13863231_2.fastq.gz	Fastqsanger.gz
	SRR13863232_1.fastq.gz	Fastqsanger.gz
	SRR13863232_2.fastq.gz	Fastqsanger.gz
	SRR13863233_1.fastq.gz	Fastqsanger.gz

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Anti-aging effects of Vicatia thibetica de Boiss root extract on Caenorhabditis elegans and doxorubicin-induced mice via promoting collagen and stress resistance

Project description:The root of Vicatia thibetica de Boiss is a Chinese herb medicine with homology of medicine and food. We first report that HLB01 (the extract of Vicatia thibetica de Boiss root) extends lifespan and promotes healthy parameters in Caenorhabditis elegans (C. elegans). In doxorubicin-induced senescent mice, HLB01 counteracts senescence associated biomarkers significantly, including AST, ALT, p21 and γH2AX. Interestingly, HLB01 promotes the level of collagen in C. elegans and mammalian cell systemically, which might be one of the essential factors to exert anti-aging effects of HLB01. In addition, HLB01 can scavenge free radical to perform antioxidant ability. Lifespan extension of HLB01 also dependent on DAF-16 and HSF-1 to perform oxidative stress resistance and heat stress resistance. Taken together, these data indicate that HLB01 extends lifespan and healthspan of C. elegans, resists doxorubicin‐induced senescence in mice via collagen promoting, antioxidant and stress resistance.

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Project description:The roots of Vicatia thibetica de Boiss are a kind of Chinese herb with homology of medicine and food. This is the first report showing the property of the extract of Vicatia thibetica de Boiss roots (HLB01) to extend the lifespan as well as promote the healthy parameters in Caenorhabditis elegans (C. elegans). For doxorubicin- (Doxo-) induced premature aging in adult mice, HLB01 counteracted the senescence-associated biomarkers, including P21 and γH2AX. Interestingly, HLB01 promoted the expression of collagen in C. elegans and mammalian cell systemically, which might be one of the essential factors to exert the antiaging effects. In addition, HLB01 was also found as a scavenger of free radicals, thereby performing the antioxidant ability. Lifespan extension by HLB01 was also dependent on DAF-16 and HSF-1 via oxidative stress resistance and heat stress resistance. Taken together, overall data suggested that HLB01 could extend the lifespan and healthspan of C. elegans and resist Doxo-induced senescence in mice via promoting the expression of collagen, antioxidant potential, and stress resistance.

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