Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ScRNA-Seq analysis of primed synovial fibroblasts

ABSTRACT: scRNA-Seq analysis of primed synovial fibroblasts

PROVIDER: PRJNA714968 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13981729.fastq.gz	Fastqsanger.gz
	SRR13981730.fastq.gz	Fastqsanger.gz
	SRR13981731.fastq.gz	Fastqsanger.gz

Items per page:

1 - 3 of 3

Similar Datasets

Proteomic analysis of synovial fibroblasts from patients with Juvenile idiopathic arthritis

Project description:The aim was to characterize the proteomic alterations in synovial fibroblasts from patients with juvenile idiopathic arthritis, with or without prior priming with inflamed synovial fluid. Synovial fibroblasts were isolated from the synovial fluid of patients with oligoarticular juvenile idiopathic arthritis via passaging. For the experiment, they were primed or not with a pool of 20% of pooled synovial fluid from patients for 48hrs.

2026-04-13 | PXD041459 | Pride

scRNA-Seq analysis of primed synovial fibroblasts

Project description:scRNA-Seq analysis of FACS sorted CD45-CD31- cells from naive and MSU crystals injected mouse paws.

2021-03-17 | GSE169051 | GEO

Transcriptomic analysis of primed synovial fibroblasts from monosodium urate crystal-induced arthritis in the mouse [RNA-seq]

Project description:Repeated challenge of synovial fibroblasts with MSU crystals in vivo induced inflammatory priming.

2021-03-17 | GSE169050 | GEO

Transcriptomic analysis of primed synovial fibroblasts from monosodium urate crystal-induced arthritis in the mouse

Project description:Transcriptomic analysis of primed synovial fibroblasts from monosodium urate crystal-induced arthritis in the mouse

| PRJNA714965 | ENA

scRNA-seq with paired V(D)J sequencing of synovial B cells from rheumatoid arthritis patients

Project description:scRNA-seq with paired V(D)J sequencing of synovial B cells from rheumatoid arthritis patients.

2023-08-01 | E-MTAB-12833 | biostudies-arrayexpress

Transcriptomic analysis of cultured primed synovial fibroblasts from monosodium urate crystal-induced arthritis in the mouse (validation set of samples)

Project description:Repeated challenge of synovial fibroblasts with MSU crystals in vivo induced inflammatory priming

2020-12-24 | GSE163749 | GEO

Transcriptomic analysis of primed synovial fibroblasts from monosodium urate crystal-induced arthritis in the mouse [RNA-seq]

Project description:Transcriptomic analysis of primed synovial fibroblasts from monosodium urate crystal-induced arthritis in the mouse [RNA-seq]

| PRJNA714967 | ENA

Proteomic Analysis of the Interaction between Chicken Synovial Fibroblasts and Mycoplasma synoviae

Project description:Chicken synovial fibroblasts was infected without or with Mycoplasma synoviae for 48h

2019-11-29 | PXD016513 |

Sequencing of dermal fibroblasts and synovial fibroblasts cultured in vitro

Project description:Knee osteoarthritis (KOA), as a degenerative multifactorial disease, affects the quality of life and mental health of patients, and also brings a huge socioeconomic burden. Treating synovitis have shown promise as anti-inflammatory therapeutics in mitigating OA symptoms and disease progression. Here, by analysing synovial single-cell sequencing (scRNA-seq) data from KOA, we found that synovial fibroblasts (FLS) in OA synovium showed a distinct pro-inflammatory phenotype. We collected synovial tissue from patients with clinical OA as well as from healthy donors, and histological examination was consistent with findings in scRNA-seq. Inspired by recent cross-tissue fibroblast lineage studies, we identified by sequencing that healthy FLS in synovial tissues share transcriptome-level similarities with dermal fibroblasts (DFb). Subsequently, we revealed the local as well as systemic distribution of intra-articular injected DFbs by constructing/extracting two types of rat fibroblasts (luciferase DFbs as well as GFP DFbs). The results demonstrate that DFbs can be locally retained in the synovium for up to three weeks following targeted engrafting on it. And intra-articular injection does not result in DFbs migration to vital organs or the occurrence of histological changes in these organs. A rat model of KOA was constructed by anterior cruciate ligament transection (ACLT) in order to study the therapeutic effect of DFbs on KOA. After injection, the rats showed improvement in painful gait. In addition, histological as well as imaging results showed reduced synovitis and improvement in articular cartilage. Finally we verified the protective effect of DFbs on cytokine-stimulated chondrocytes in a co-culture system.

2025-01-13 | GSE285940 | GEO

scRNA-seq reveals transcriptional profiling of telocytes in synovial tissue

Project description:This study employs scRNA-seq to characterize Efhd1⁺ tdTomato⁺ telocyte-like cells isolated from knee synovial tissues. By comparing their transcriptional profiles to fibroblasts, we aim to delineate distinct cellular phenotypes and understand telocyte heterogeneity across tissue microenvironments. Our analysis reveals unique gene expression signatures defining telocytes providing insights into their potential roles in tissue homeostasis and fibrosis.

2026-02-13 | GSE303999 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data