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TranscriptomicsCSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline
P granules in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency.  Sterility in the absence of P granules is often accompanied by the mis-expression of soma-specific proteins and the initiation of somatic differentiation in germ cells.  To investigate ...
ORGANISM(S): Caenorhabditis elegans 
2015-05-20 | E-GEOD-67954 | biostudies-arrayexpress
ProteomicsProteomic Analysis of fly brain cytoplasmic RNP granules containing the lncRNA mimi
In neurons, mRNAs and associated RNA-binding proteins assemble into ribonucleoprotein (RNP) granules essential to regulate mRNA trafficking, local translation, and turnover. Dysregulation of RNA-protein condensation can disturb synaptic plasticity. We report that the novel lncRNA mimi is a constitut...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-12 | PXD034453 | Pride
Rnp granules  fly brain  neurons  lncrna mimi Fne  rbp9 Drosophila  relative ibaq  quantitative proteomics 
TranscriptomicsTracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: a Link Between Stalled Polyribosomes and RNA Granules
Local translation at the synapse plays key roles in neuron development and activity-dependent synaptic plasticity. mRNAs are translocated from the neuronal soma to the distant synapses as compacted ribonucleoparticles referred to as RNA granules. These contain many RNA-binding proteins, including th...
ORGANISM(S): Mus musculus 
2016-06-30 | E-GEOD-83835 | biostudies-arrayexpress
GenomicsRNA localization to stress granules
RNA localization to stress granules
PRJNA875210 | ENA
TranscriptomicsRNA-seq of Rattus novergicus brain after stroke with Yangyin Tongnao granules for the treatment of the cerebral ischemia-reperfusion injury
In this study, the aim was to elucidate the mechanism of ischemic stroke in rats using a novel integrated transcriptomic. Transcriptomic data were obtained by Illumina-based RNA-seq technology. Then, transcriptomics was applied to dig out the reversed differentially expressed targets against IS indu...
ORGANISM(S): Rattus norvegicus 
2023-08-23 | E-MTAB-12143 | biostudies-arrayexpress
GenomicsRNA damage compartmentalization by DHX9 granules
RNA damage compartmentalization by DHX9 granules
PRJNA902687 | ENA
GenomicsGerm Granules Govern Small RNA Inheritance
Germ Granules Govern Small RNA Inheritance
PRJNA526484 | ENA
GenomicsRNA in Trypanosoma brucei heat shock granules
RNA in Trypanosoma brucei heat shock granules
PRJEB12996 | ENA
GenomicsDistinct Dynamics and Composition of Endogenous Neuronal RNA Granules
Distinct Dynamics and Composition of Endogenous Neuronal RNA Granules
PRJNA1445255 | ENA
ProteomicsInterference of RNA molecules with protein aggregation in vitro.
The analysis of RNA-protein interactomes indicates that the amount of structure in RNA molecules correlates with the capacity of binding to proteins in vitro and in vivo. To validate this observation, we used an in vitro network that mimics the composition of phase-separated RNA granules. The interf...
ORGANISM(S): Homo sapiens (Human) 
2019-09-13 | PXD011751 | Pride
B-isox Rna interactivity Rna granules 
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