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ProteomicsDifferential Enzymatic 16O/18O Labelling for the Detection of Cross-Linked Nucleic Acid-Protein Heteroconjugates
Enzymatic differential 16O/18O labelling of nucelic acid-protein heteroconjugates. Heteroconjugates are identified against a complex background using an automated analysis workflow.
ORGANISM(S): Bos taurus (Bovine) 
2017-09-11 | PXD003673 | Pride
Lc-ms Cross-linking Nucelic acid-protein heteroconjugates 
ProteomicsValidation of a novel shotgun proteomic workflow for the discovery of protein-protein interactions: focus on ZNF521
The study of protein-protein interactions is increasingly relying on mass spectrometry (MS). The classical approach of separating immunoprecipitated proteins by SDS-PAGE followed by in-gel digestion is long and labour-intensive. Besides, it is difficult to integrate it with most quantitative MS-base...
ORGANISM(S): Homo sapiens (Human) 
2015-04-07 | PXD001609 | Pride
Ap-ms  interactomics  18o labelling  znf521  znf423  spt16  spt5  nurd core complex  proteomics  mass spectrometry  shotgun proteomics 
ProteomicsAP-MS of helicase Upf1 in PC12 cells
DNA/RNA helicase Upf1 seems to interact with axonal transcripts in response to nerve growth factor (NGF, A. Ludanyi, M. Gaspari and A. Riccio, unpublished data). In order to shed light on Upf1 mechanism of action and to identify potential associations with molecules having cleavage activity, we perf...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-10 | PXD023586 | Pride
Protein complex Hud Ago2 Impa1 
ProteomicsQuantitative analysis of in vivo methionine oxidation of the human proteome
A novel stable isotope labelling strategy was developed to quantify methionine oxidation in an unstressed human proteome. Cell extracts were oxidized with 18O labelled hydrogen peroxide following cell lysis in order to convert all unoxidized methionine residues to an oxidized version with a heavy l...
ORGANISM(S): Homo sapiens (Human) 
2019-12-09 | PXD014629 | Pride
Methionine oxidation Unstressed proteome Human cell line 
UnknownStable Isotope Phosphate Labelling of Diverse Metabolites is Enabled by a Family of 18O-Phosphoramidites.
Not available
S-EPMC10947094 | biostudies-literature
UnknownAn Improved Isotope Labelling Method for Quantifying Deamidated Cobratide Using High-Resolution Quadrupole-Orbitrap Mass Spectrometry.
Not available
S-EPMC9572859 | biostudies-literature
ProteomicsThe Bordetella pertussis and Bordetella bronchiseptica filamentous hemagglutinins are processed at different sites
Mapping of the C-terminal residues of FHA from Bordetellae utilizing differential 16O/18O labelling
ORGANISM(S): Bordetella pertussis Bordetella bronchiseptica RB50 
2018-10-22 | PXD008664 | Pride
Filamentous hemagglutinin Sphb1 protease Bordetella pertussis Bordetella bronchiseptica 
ProteomicsMicrodissected pyramidal cell proteomics of Alzheimer brain reveals alterations in Creatine Kinase B, 14-3-3-g and Heat Shock Cognate 71
Novel insights on proteins involved in Alzheimer disease (AD) are needed. Since multiple cell types and matrix components are altered in AD, bulk analysis of brain tissue may be difficult to interpret. In the current study, we isolated pyramidal cells from the CA1 region of the hippocampus from five...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028282 | Pride
Quantitative ms Alzheimer disease Q exactive Homo sapiens O18 labelling 
UnknownA linear pathway for inositol pyrophosphate metabolism revealed by 18O labeling and model reduction.
Not available
S-EPMC12626311 | biostudies-literature
ProteomicsProteomics of Alzheimer's Disease mouse models - control dataset
Alzheimer’s disease (AD) is a neurodegenerative disease displaying plaques formed by the neurotoxic amyloid β-peptide (Aβ), and intracellular neurofibrillary tangles consisting of protein tau. However, how these pathologies relates to the massive neuronal death that occurs in AD brains remain elusiv...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-29 | PXD001786 | Pride
Mouse brain 
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