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TranscriptomicsTranscription profiling time series of human RKO cell line responses to 2-hydroxy-2-nonenal
Cellular responses to 4-hydroxy-2-nonenal (HNE)--dose response and time course--three replicate experiments for each treatment
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2397 | biostudies-arrayexpress
ProteomicsHNE-modification identification of ApoAI
In this research, two 4-hydroxy-2-nonenal modified peptides with differential performance were identified in the plasma of patients with coronary artery disease, whether their antibodies were different in the plasma of patients with coronary artery disease and healthy people.
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD041969 | Pride
Two 4-hydroxy-2-nonenal Apolipoprotein ai Coronary artery disease Autoantibody 
Genomics4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes
4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes
PRJNA631421 | ENA
Transcriptomics4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes
Pathogens must counteract a wide array of antimicrobial responses, including the reactive oxygen species (ROS) burst. ROS mediated oxidation of host membrane poly-unsaturated fatty acids (PUFAs) leads to the production of the toxic alpha-beta carbonyl 4-hydroxy-2-nonenal (4-HNE). 4-HNE has been stud...
ORGANISM(S): Listeria monocytogenes 10403S 
2020-05-10 | GSE150188 | GEO
TranscriptomicsLJMJDW: Cellular responses to 4-hydroxy-2-nonenal
Cellular responses to 4-hydroxy-2-nonenal (HNE)--dose response and time course--three replicate experiments for each treatment Keywords: other
ORGANISM(S): Homo sapiens 
2005-12-01 | GSE2397 | GEO
TranscriptomicsTranscription profiling of human HLE B-3 cells transfected with hGSTA4-4 expressing vector vs. controls
HLE B-3 cells were transfected with either empty vector or hGSTA4-4 expressing vector to lower intracellular 4-hydroxynonenal levels. hGSTA4-transfected sample has lower HNE levels than pTarget-transfected sample.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2298 | biostudies-arrayexpress
GenomicsHomo sapiens
LJMJDW: Cellular responses to 4-hydroxy-2-nonenal
PRJNA91599 | ENA
TranscriptomicsEffect of 4-Hydroxynonenal on gene expression. Comparison of HSF1-siRNA silenced vs control cells
4-Hydroxynonenal (HNE), a cytotoxic and diffusible electrophile generated by the spontaneous decomposition of oxidized lipids, has a suspected role in neurodegenerative and inflammatory disease processes. In addition to promoting cell death, elevated levels of HNE lead to the engagement of cytoprote...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-12762 | biostudies-arrayexpress
ProteomicsThe Carnosine–HNE Michael Adduct as a Redox-Active Species Associated with Nrf2-Dependent Antioxidant and An-ti-Inflammatory Responses
Carnosine (CAR), an endogenous histidine-containing dipeptide, exhibits antioxidant and anti-inflammatory activity in various experimental models; however, its molecular mechanism of action remains poorly understood. Here, we demonstrate that the Michael adduct between CAR and 4-hydroxy-2-nonenal (H...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD075159 | Pride
Carnosine  4-hydroxy-2-nonenal (hne)  nrf2 activation  nf-κb  anti-inflammatory  anti-oxidant. 
UnknownGlutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver.
Not available
S-EPMC4040968 | biostudies-literature
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