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TranscriptomicsRibosome hibernation factor promotes Staphyloccocal survival and differentially represses translation
We sequenced a total of 16 cDNA libararies derived from fragmented total mRNA and ribosome protected mRNAs from S. aureus hpf mutant (NE838) and its parental strain JE2 grown in tryptic soy broth (TSB) or minimal medium (MM). The data represented 2 independent biological replicates. Examination of t...
ORGANISM(S): Staphylococcus aureus 
2016-03-29 | E-GEOD-74197 | biostudies-arrayexpress
TranscriptomicsInitiation Pausing of 80S Ribosome on mRNA Is Governed by 5'UTR and Responsive to mTORC1 Signaling (RNA-Seq)
Recent studies have revealed that the mRNA translation is punctuated by ribosomal pauses through the body of transcripts. However, little is known about its physiological significance and regulatory aspects. Here we present a multi-dimensional ribosome profiling approach to quantify the dynamics o...
ORGANISM(S): Mus musculus 
2011-11-12 | E-GEOD-25626 | biostudies-arrayexpress
ProteomicsExpanding the cross-link coverage of a dihydrazide-based carboxyl-group specific chemical cross-linking strategy - Dataset 3: E. coli 70S ribosome
The conditions for chemical protein-protein cross-linking using the reagents pimelic dihydrazide (PDH) and 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium (DMTMM) chloride were optimized using a set of five model proteins and two large complexes, the 20S proteasome and the 70S ribosome. Th...
ORGANISM(S): Escherichia coli 
2021-01-04 | PXD019508 | Pride
Chemical cross-linking  pdh  dmtmm  70s ribosome  method optimization 
ProteomicsA new family of ribosome hibernation factors in ArchaeaA new family of ribosome hibernation factors in Archaea
Ribosome hibernation preserves translation machinery during stress, yet its mechanisms in Archaea remain poorly defined. Here, we identify HibA, a previously unrecognized family of hibernation factors widespread in Archaea. HibA consists of a bacterial-like HPF/RaiA domain fused to a Cystathionine B...
ORGANISM(S): Pyrococcus abyssi GE5 
2026-03-24 | PXD073243 | Pride
Archaea Ribosome Hibernation 
ProteomicsRibosome protein composition in wt and 23S+5S rRNA ribosomes
The 120-nt long 5S rRNA, is an indispensable component of cytoplasmic ribosomes in all living organisms. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear. Here we used ribosome engineering to investigate whether maintaining 5S rRNA ...
ORGANISM(S): Escherichia coli 
2020-06-18 | PXD019058 | Pride
Mass-spectrometry Ribosome Proteins 
ProteomicsWblC- and tetracycline-dependent shifts in the composition of Streptomyces coelicolor ribosomal proteome
WblC, also known as WhiB7, is a widely conserved WhiB-like transcription factor in actinomycetes that activates transcription of many targets upon antibiotic challenge to bring about intrinsic resistance to a wide range of translation-targeting antibiotics. As we found that WblC controls many genes ...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2020-05-27 | PXD015538 | Pride
Streptomyces coelicolor Ribosome Whib7 Wblc Antibiotic stress 
UnknownThe 70S ribosome modulates the ATPase activity of Escherichia coli YchF.
Not available
S-EPMC3583859 | biostudies-literature
UnknownCryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH.
Not available
S-EPMC10799931 | biostudies-literature
UnknownThiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4.
Not available
S-EPMC3245911 | biostudies-literature
UnknownStructural diversity in bacterial ribosomes: mycobacterial 70S ribosome structure reveals novel features.
Not available
S-EPMC3286452 | biostudies-literature
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