601205 Results

Show all   Save search   Copy query
Sort   by:  
 Page size 
MetabolomicsTrans-tissue molecular coordination in high-intensity physical activity
High-intensity physical activity has major impacts in different parts of the body. However, the regulatory coordination between different tissues to support the high physical demands is poorly understood. Here we performed a multi-omics analysis of blood plasma, urine and saliva from a group of fire...
2025-07-03 | MTBLS1891 | MetaboLights
MetabolomicsMetabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype
The relationship between sequence variation and phenotype is poorly understood. Here, we use metabolomic analysis to elucidate the molecular mechanism underlying the filamentous phenotype of E. coli strains that carry destabilizing mutations in dihydrofolate reductase (DHFR). We find that partial lo...
2021-06-30 | MTBLS2795 | MetaboLights
MetabolomicsMulti-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces
Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views ...
2020-01-23 | MTBLS721 | MetaboLights
MetabolomicsAngiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.

OBJECTIVE: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity.

2023-11-15 | MTBLS4082 | MetaboLights
MetabolomicsMitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth

Prostate cancer (PCa) growth depends on de novo lipogenesis controlled by the mitochondrial pyruvate dehydrogenase complex (PDC). In this study, we identified lysine methyltransferase (KMT)9 as a novel regulator of PDC activity. KMT9 is localized in mitochondria of PCa cells, but not in mitochond...

2024-12-10 | MTBLS2452 | MetaboLights
MetabolomicsVariety-Specific Polyphenol Accumulation and Antioxidant Activity Differences in Apple Fruits

Oxidative stress is a key inducer of chronic diseases, and apple polyphenols exhibit significant antioxidant potential. This study systematically analyzed polyphenol accumulation characteristics and antioxidant activity of four apple cultivars (Qincui, Jiuyue Qiji, Orin, Ruixue) using a multi-lev...

2026-01-14 | MTBLS13681 | MetaboLights
MetabolomicsImpact of reproductive activity on physiological metabolism and molecular regulation in the Genus scallopus(Mizuhopecten yessoensis)

Genus scallopus(Mizuhopecten yessoensis), a commercially important shellfish species in China, suffers a persistently high post-spawning mortality rate, severely constraining industry development. Thus, this study investigated the physiological and molecular impact of reproductive activity on M. ...

2025-06-28 | MTBLS12652 | MetaboLights
MetabolomicsMetabolite control of enzyme activity links stress to biosynthetic regulation

Cells must continuously adjust metabolic output to maintain homeostasis under changing environmental conditions, yet the mechanisms that enable rapid and reversible control of pathway activity remain largely unknown. The methylerythritol phosphate (MEP) pathway, of bacterial origin and conserved ...

2026-02-04 | MTBLS12456 | MetaboLights
MetabolomicsEffect of Zanthoxylum bungeanum essential oil on rumen enzyme activity, microbiome, and metabolites in lambs

Antibiotics were once used in animal production to improve productivity and resistance to pathogenic microbiota. However, due to its negative effects, the search for a new class of substances that can replace its efficacy has become one of the urgent problems to be solved. Plant essential oils (E...

2022-09-13 | MTBLS3683 | MetaboLights
MetabolomicsDynamic change of IDO1 activity predicts survival in patients with unresectable stage III NSCLC and chemoradiotherapy

OBJECTIVES: High activity of Indoleamine 2,3-dioxygenase1 (IDO1) in lung cancer patients converts tryptophan (Trp), which is the essential amino acid for T cell metabolism, to kynurenine (Kyn) and consequently suppresses anti-tumor immune responses. We aimed to track the dynamics...

2022-08-05 | MTBLS5267 | MetaboLights
Sort   by:  
 Page size