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MetabolomicsDual Effects of Fasting on Gut Microbiota and Metabolism: Protective Adaptation versus Barrier Dysfunction Risks
Fasting is increasingly recognized as a metabolic intervention that reshapes gut microbiota and host metabolism, but its duration-dependent effects on intestinal epithelial integrity remain incompletely understood. In this study, we compared ad libitum feeding, 12 h fasting, and 24 h fasting in male...
2026-07-20 | MTBLS15098 | MetaboLights
MetabolomicsImpact of acute lymphoblastic leukemia induction therapy: findings from metabolomics on non-fasted plasma samples from a biorepository

INTRODUCTION: Acute lymphoblastic leukemia (ALL) is among the most common cancers in children. With improvements in combination chemotherapy regimens, the overall survival has increased to over 90%. However, the current challenge is to mitigate adverse events resulting from the c...

2021-08-12 | MTBLS2394 | MetaboLights
MetabolomicsAlterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation

Acute stroke (AS) is a major public health issue globally, exhibiting high morbidity, disability rate, and mortality. Emerging research has demonstrated the critical roles of gut microbiota and its metabolites in pathogenesis, recovery, and prognosis of AS. In this study, we investigated alterati...

2025-08-06 | MTBLS12822 | MetaboLights
ProteomicsAltered Metabolomics and Inflammatory Transcriptomics in Human Bone Marrow Adipocytes After Acute High Calorie Diet and Acute Fasting
Investigated bone marrow metabolism in response to acute overnutrition (high calorie diet) and calorie deprivation (fasting). Bone marrow serum and peripheral serum were collected before and after each dietary intervention. Using proteomics analyses of the sera, we characterized nutritional influenc...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD063552 | Pride
Human  acute high calorie diet  acute fasting  bone marrow serum  peripheral blood serum  proteomics  mass spectrometry 
TranscriptomicsIntermittent fasting promotes remodeling of neural and vascular networks in visceral white adipose tissue
Intermittent fasting (IF) improves metabolic health, in part by remodeling white adipose tissue (WAT), yet the underlying mechanisms remain elusive. Here, we show that IF induces coordinated neurovascular remodeling in visceral WAT, marked by increased angiogenesis and sympathetic innervation. Using...
ORGANISM(S): Mus musculus 
2026-07-13 | E-MTAB-16066 | biostudies-arrayexpress
MetabolomicsAcute response to a high-saturated, high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways

Regular consumption of fat and refined carbohydrates induces metabolic stress, increasing chronic metabolic disease risk. In healthy volunteers, we characterised the response to a high-fat/high-carbohydrate meal (HFHCM), typical of an ultra-processed food, by proteomic and metabolomics analyses, ...

2026-04-02 | MTBLS10972 | MetaboLights
GenomicsSystemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice
Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice
PRJNA1174773 | ENA
ProteomicsSpermidine is essential for fasting-mediated autophagy and longevity
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health 1. The natural polyamine spermidine has been linked to autophagy regulation, geroprotection and reduced incidence of cardiovascular and neurodegenerative diseases across speci...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-04-30 | PXD035909 | Pride
Autophagy Nanolc-ms/ms Spermidin Fasting Yeast Human Lifespan Eif5a hypusination Mouse C.elegans 
GenomicsRepeated Bouts of 24-hour Intermittent Fasting Attenuates Arterial Stiffness in Obese Mice Via Sustained Alterations to a Gut-Immune-Vascular Axis
Acute Arm of the 24-hour Intermittent Fasting Study
PRJEB99021 | ENA
TranscriptomicsAltered Metabolomics and Inflammatory Transcriptomics in Human Bone Marrow Adipocytes After Acute High Calorie Diet and Acute Fasting
Expansion of bone marrow adipocytes has been linked to nutritional pressures, suggesting that bone marrow is a dynamic compartment that responds to fluctuations in systemic nutritional availability to regulate osteogenesis and hematopoiesis. Here we investigated bone marrow metabolism in response to...
ORGANISM(S): Homo sapiens 
2025-05-24 | GSE297963 | GEO
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