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TranscriptomicsSpermidine Yeast Aging Array
Administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extends the lifespan of various model organisms including yeast, flies and worms. In ageing yeast, spermidine treatment triggeres epigenetic deacetylation of histone H3 through...
ORGANISM(S): Saccharomyces cerevisiae 
2012-01-04 | E-MTAB-912 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae mutant delta-spe3 delta-fms1 after spermidine treatment
The naturally occurring polyamines putrescine, spermidine or spermine are ubiquitous in all cells. Although polyamines have prominent regulatory roles in cell division and growth, precise molecular and cellular functions are not well established in vivo. In this work we have performed a microarray e...
ORGANISM(S): Saccharomyces cerevisiae 
2009-09-05 | E-GEOD-15269 | biostudies-arrayexpress
ProteomicsThe analysis of spermidine-binding proteins
Our study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. This process is regulated by methionine metabolite spermidine，which can bind with proteins to regulate their biological function. Thus，the binding proteins of sp...
ORGANISM(S): Homo Sapiens 
2025-01-21 | PXD060003 |
TranscriptomicsHuman Hair follicles: Control Vs. 0.5 µM spermidine treatment
To compare the effects of spermidine, key polyamine, on the gene expression profile of organ cultured human hair follicles Vehicle treated Vs. 0.5 µM spermidine treatment. Two control samples, two spermidine treated samples
ORGANISM(S): Homo sapiens 
2011-04-16 | E-GEOD-28650 | biostudies-arrayexpress
TranscriptomicsRNA sequencing in fly heads to examine the effect of spermidine feeding on transcription in the ageing fly brain.
mRNA sequencing was used to identify genome wide transcriptional changes occuring in fly heads in response to spermidine feeding. This study shed light on the molecular mechanisms through wich spermidine can protect against age-dependent memory impairment. mRNA profiles from 3 and 10 day old Drosoph...
ORGANISM(S): Drosophila melanogaster 
2013-09-01 | E-GEOD-38998 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT)
Type 2 diabetes is a complex disorder due to defects in insulin secretion and insulin action. Therefore, we investigated mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT) have reduced amount of white adipose tissue, high basal metabolic rate, improved glucose tolerance, high insul...
ORGANISM(S): Mus musculus 
2007-04-25 | E-MEXP-165 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of polyamine responsive genes
Genes differentially expressed by exogenously supplied polyamines: putrescine, spermidine, spermine, thermospermine and cadaverine in Arabidopsis thaliana.
ORGANISM(S): Arabidopsis thaliana 
2020-08-25 | E-MTAB-9267 | biostudies-arrayexpress
Proteomicsspermine and spermidine standards
Spermine and spermidine pure standards for level 1 annotation confidence.
ORGANISM(S): Not Applicable 
2024-04-30 | MSV000094647 | MassIVE
ProteomicsThe analysis of GSDME-NT binding proteins in the presence or absence of methionine
Our study identify that methionine inhibits N-terminus of GSDME (GSDME-NT) -mediated pyroptosis by dampening its endocytotic degradation. Thus，the binding proteins of GSDME-NT are detected in the presence or absence of Methionine for futher exploration。
ORGANISM(S): Homo Sapiens 
2025-01-19 | PXD059954 |
TranscriptomicsMicroarray-based Analysis of Polyamine Transport and Metabolism in the Model Marine Bacterium Silicibacter pomeroyi
Polyamines, such as putrescine and spermidine, are aliphatic organic compounds with multiple amino groups. They are found ubiquitously in marine systems. However, compared with the extensive studies on the concentration and fate of other dissolved organic nitrogen compounds in seawater, such as diss...
ORGANISM(S): Silicibacter pomeroyi 
2010-05-14 | E-GEOD-13781 | biostudies-arrayexpress
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