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ProteomicsOCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
3D spheroids of primary human hepatocytes (3D PHH) keep a differentiated phenotype with retained metabolic function and proteome fingerprint for weeks in culture. As a result, 3D PHH are gaining ground as a model for mechanistic studies on liver homeostasis and in vitro to in vivo (IVIV)predictions...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD045733 | Pride
Human Hepatocytes Adme Liver 
UnknownComparative untargeted proteomic analysis of ADME proteins and tumor antigens for tumor cell lines.
Not available
S-EPMC5925393 | biostudies-literature
ProteomicsGASP and FASP are complementary for LC-MS/MS proteomic analysis of drug-metabolising enzymes and transporters in pig liver
Sample preparation is a critical step in the proteomic workflow. Numerous different approaches are used, tailored to the type of sample, the aims of the experiment, analytical method, and to an extent, user preference. This has resulted in large variation in reported protein abundances. In this stud...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2018-11-12 | PXD011324 | Pride
Gasp Sample preparation Fasp Pig liver Lc-ms/ms 
ProteomicsInter-Laboratory Variability in the Madin-Darby Canine Kidney Cell ProteomeInter-Laboratory Variability in the Madin-Darby Canine Kidney Cell Proteome
Madin-Darby Canine Kidney (MDCK) cells are widely used to study epithelial cell functionality. Their low endogenous drug transporter protein levels make them an amenable system to investigate trans-epithelial permeation and drug transporter protein activity after their transfection. MDCK cells displ...
ORGANISM(S): Zea mays (Maize) 
2023-07-20 | PXD039552 | Pride
Label-free proteomics  total protein analysis (tpa)  mdck  epithelial proteome  adme protein abundances 
ProteomicsAge Shapes the Protein Corona: Unraveling the Impact of Biological Aging on Nanoparticle Identity and Function
Aging profoundly influences the composition of biological fluids, including the plasma proteome and lipidome, yet its effects on the protein coronas (PC) forming around nanoparticles (NPs) remain poorly understood. Here, we investigate how age-dependent changes in plasma proteins and lipids modulate...
ORGANISM(S): Mus Musculus 
2025-04-02 | PXD062545 |
ProteomicsProteome changes in monocytic THP-1 cells induced by 31 engineered nanomaterials
Here, we investigated a panel of 31 engineered nanomaterials (ENMs) with different core chemistries and surface modifications using conventional cytotoxicity assays coupled with omics-based approaches. Proteomics analysis were conducted in order to monitor changes in cells proteome exposed to ENMs. ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019267 | Pride
Immunotoxicology Proteomics Mass spectrometry Nanomaterials Nanotoxicology 
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