Sort   by:  
 Page size 
MetabolomicsMulti-omics toxicity profiling of engineered nanomaterials

This study aims to implement methods for toxicological profiling of engineered nanomaterials using toxicogenomics, proteomics, and metabolomics along with computational analyses. For all three omics layers the human cell lines A549 (lung epithelial cells) and THP1 (monocytes) were separately expo...

2016-12-05 | MTBLS277 | MetaboLights
MetabolomicsMulti-hierarchical profiling the structure-activity relationships of engineered nanomaterials at nano-bio interfaces
Increasing concerns over the possible risks of nanotechnology necessitates breakthroughs in structure-activity relationship (SAR) analyses of engineered nanomaterials (ENMs) at nano-bio interfaces. However, current nano-SARs are often based on univariate assessments and fail to provide tiered views ...
2020-01-23 | MTBLS721 | MetaboLights
ProteomicsRevealing the immune perturbation of black phosphorus nanomaterials to macrophages by understanding the protein corona
The increasing number of biological applications for black phosphorus (BP) nanomaterials has precipitated considerable concern about their interactions with physiological systems. Here, we demonstrate the adsorption of plasma protein onto BP nanomaterials and the subsequent immune perturbation effec...
ORGANISM(S): Homo sapiens (Human) 
2018-05-18 | PXD009645 | Pride
Corona Human plasma Black phosphorus nanomaterials Lc-ms/ms 
ProteomicsNanomaterials trigger functional responses in primary human immune cells
Targeting the immune system with nanoparticles (NPs) to deliver immunomodulatory molecules emerged as a solution to address intra-tumoral immunosuppression and enhance therapeutic response. While the potential of nanoimmunotherapies in reactivating immune cells has been evaluated in several preclini...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD056695 | Pride
Nanomaterials  human lymphocytes  nlc-ms/ms  sp3-spe  differential analysis 
GenomicsCIP anaerobic removal with carbon nanomaterials
Ciprofloxacin anaerobic removal with carbon nanomaterials
PRJEB43083 | ENA
GenomicsEffects of Engineered Nanomaterials on Mouse Airways: Assessment of 28 Nanomaterials.
Effects of Engineered Nanomaterials on Mouse Airways: Assessment of 28 Nanomaterials.
PRJNA660731 | ENA
TranscriptomicsMRNA-Integrative multi-omics survey of effects carbon-based engineered nanomaterials on lung derived cell-lines
In this study we exposed three human lung derived cell lines to sublethal dosages of nanomaterials for a limited amount of time. For the first time, we assessed the simultaneous effects of nanomaterials exposure on three distinct molecular layers along with their interactions in the determination of...
ORGANISM(S): Homo sapiens 
2018-05-19 | E-MTAB-6396 | biostudies-arrayexpress
TranscriptomicsMIRNA - Integrative multi-omics survey of effects carbon-based engineered nanomaterials on lung derived cell-lines
In this study we exposed three human lung derived cell lines to sublethal dosages of nanomaterials for a limited amount of time. For the first time, we assessed the simultaneous effects of nanomaterials exposure on three distinct molecular layers along with their interactions in the determination of...
ORGANISM(S): Homo sapiens 
2018-05-19 | E-MTAB-6406 | biostudies-arrayexpress
TranscriptomicsDNA-METHYLATION - Integrative multi-omics survey of effects carbon-based engineered nanomaterials on lung derived cell-lines
In this study we exposed three human lung derived cell lines to sublethal dosages of nanomaterials for a limited amount of time. For the first time, we assessed the simultaneous effects of nanomaterials exposure on three distinct molecular layers along with their interactions in the determination of...
ORGANISM(S): Homo sapiens 
2018-05-19 | E-MTAB-6397 | biostudies-arrayexpress
ProteomicsSelective Regulation of Macrophage Lipid Metabolism via Nanomaterials’ Surface Chemistry
Understanding the interfacial structure between nanomaterials and lipoproteins is crucial for gaining profound insights into how nanomaterials impact lipoprotein structure and interfere with lipid metabolism. In this study, we employed graphene oxide (GO) nanosheets (NSs) with precisely controlled s...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044475 | Pride
Human plasma Low density lipoprotein Lc-ms Lipid metabolism Graphene oxide Surface hydrophilicity 
Sort   by:  
 Page size