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MetabolomicsThe influence of Pseudomonas aeruginosa infection on the airway metabolome
Pseudomonas aeruginosa is an environmentally resilient bacterium and an important cause of both acute and chronic infections in people with impaired natural barriers or immunological defences. Chronic respiratory infection with P. aeruginosa is a major cause of morbidity and mortality in people with...
2025-11-06 | MTBLS6052 | MetaboLights
TranscriptomicsReduced Airway Surface pH Impairs Bacterial Killing in the Porcine Cystic Fibrosis Lung
Cystic fibrosis (CF) is a life-shortening disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Although bacterial lung infection and the resulting inflammation cause most of the morbidity and mortality, how loss of CFTR first disrupts airway host defen...
ORGANISM(S): Sus scrofa 
2012-03-29 | E-GEOD-36906 | biostudies-arrayexpress
MetabolomicsMulti-omics Analysis Reveals New Insights into Yak Lung Fibrosis Mechanisms Under High-Altitude Adaptation

The lung of yak is an important adaptive organ in the cold and low oxygen environment. Hypoxia can induce the pathological manifestations of pulmonary fibrosis in yak, but there was no study on hypoxia induced pulmonary fibrosis in yak. In this study full target metabolomics were used to conduct ...

2025-07-07 | MTBLS11648 | MetaboLights
TranscriptomicsmiRNA expression profiling in Cystic Fibrosis Airway Epithelium
Cystic fibrosis (CF) is one of the commonest lethal genetic diseases in which the role of microRNAs (miRNAs) has yet to be explored. We hypothesized that unique miRNA expression profiles exist in CF versus non-CF bronchial epithelial cells so the our aim was to investigate whether unique miRNA expre...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-19431 | biostudies-arrayexpress
TranscriptomicsExpression data of cystic fibrosis and non-cystic fibrosis airway cell lines under oxidative stress
CF's physiopathology is poorly explained by the mutation alone. The oxydative stress could be a major factor of this illness . Study its impact on transcriptome's CF cell line could be ameliorate our understanding of the evolution of cystic fibrosis. we used microarray technology to evaluate under ...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-39843 | biostudies-arrayexpress
TranscriptomicsPseudomonas aeruginosa lasR mutants in young cystic fibrosis patients
Pseudomonas aeruginosa undergoes genetic change during chronic infection of the airways of cystic fibrosis (CF) patients. One common change is mutation of lasR. LasR is a transcriptional regulator that responds to one of the quorum sensing signals in P. aeruginosa, and regulates acute virulence fa...
ORGANISM(S): Pseudomonas aeruginosa 
2010-06-30 | E-GEOD-5560 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse C57Bl6 MMP-7 and MMP-10 deficient mice Pseudomonas aeruginosa exposed airway epithelium.
Airway epithelium is the initial point of host-pathogen interaction in Pseudomonas aeruginosa infection, an important pathogen in cystic fibrosis and nosocomial pneumonia. We used global gene expression analysis to determine airway epithelial transcriptional responses dependent on matrilysin (MMP-7)...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7957 | biostudies-arrayexpress
TranscriptomicsInflammatory activation of airway epithelial cells by pyocyanin
Despite the appreciated in vivo role of the redox-active Pseudomonas virulence factor pyocyanin in Pseudomonas airway infections and the recognized importance of airway epithelial cells in combating bacterial pathogens, little is known about pyocyaninM-bM-^@M-^Ys effect on airway epithelial cells. W...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-22430 | biostudies-arrayexpress
TranscriptomicsCystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
Lung disease causes most of the morbidity and mortality in cystic fibrosis (CF). However, understanding its pathogenesis has been hindered by lack of an animal model with characteristic features of CF. To overcome this problem, we recently generated pigs with targeted CFTR genes. We now report that ...
ORGANISM(S): Sus scrofa 
2010-09-17 | E-GEOD-21071 | biostudies-arrayexpress
Proteomicsγ-glutamylcysteine (GGC) supplementation and p-LPS challenge causes distinct proteomic changes to primary airway epithelial cell models of Cystic Fibrosis
Cystic fibrosis (CF) is a life limiting inherited condition associated with recurrent bacterial infections, inflammation, oxidative stress and loss of lung function. CF is characterised by deficiencies in both intra- and extracellular glutathione (GSH) levels. This GSH depletion is exacerbated by ba...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019084 | Pride
Lps Glutathione Cystic fibrosis Airway epithelial cells Qlc-ms/ms Γ-glutamylcysteine Oxidative stress 
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