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MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 1)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS204 | MetaboLights
MetabolomicsMetabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites (Cohort 2)

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to Graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced...

2019-11-06 | MTBLS205 | MetaboLights
ProteomicsA TCR blocking HLA-A*11:01-specific human monoclonal antibody
Cross-linking mass spectrometry and Targeted cross-linking mass spectrometry for a TCR blocking human monoclonal antibody targeting HLA-A*11:01
ORGANISM(S): Homo Sapiens (human) 
2025-06-02 | PXD053836 | JPOST Repository
TranscriptomicsAllogeneic mature human dendritic cells generate superior alloreactive regulatory T cells in the presence of IL-15
Introduction: Expansion of antigen (Ag)-specific natural occurring regulatory T cells (nTregs) is required to obtain sufficient numbers of cells for cellular immunotherapy. In this study, different allogeneic stimuli were studied for their capacity to generate functional alloAg-specific nTregs. Meth...
ORGANISM(S): Homo sapiens 
2015-04-20 | E-GEOD-66385 | biostudies-arrayexpress
ProteomicsPromiscuity of peptides presented in HLA-DP molecules from different immunogenicity groups is associated with T-cell cross-reactivity
In the context of HLA-DP-mismatched allogeneic stem cell transplantation, mismatched HLA-DP alleles can provoke profound allo-HLA-DP-specific immune responses from the donor T-cell repertoire leading to graft-versus-leukemia effect and/or graft-versus-host disease in the patient. The magnitude of al...
ORGANISM(S): Homo sapiens (Human) 
2022-02-12 | PXD030591 | Pride
Allosct Dpc-classification Cd4 t-cell clones Peptidome Hla-dp Cross-reactivity 
TranscriptomicsGene expression analysis of molecules with known function in HLA class II antigen processing and presentation in hematopoietic and (cytokine pre-treated) non-hematopoietic cells.
Gene expression analysis of molecules with known function in HLA class II antigen processing and presentation. Various hematopoietic cell types and (cytokine pre-treated) non-hematopoietic cells that are targeted in Graft-versus-Leukemia reactivity and Graft-versus-Host Disease were collected. Expre...
ORGANISM(S): Homo sapiens 
2012-06-18 | E-GEOD-38798 | biostudies-arrayexpress
TranscriptomicsProstaglandin dose response on hematopoietic stem cells (25 & 37 deg C)
Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs) for use in allogeneic transplantation. Key advantages of UCB are rapid availability and less stringent requirements for HLA matching. However, UCB contains an inherently limited HSC count, which is associated with del...
ORGANISM(S): Homo sapiens 
2013-09-12 | E-GEOD-48541 | biostudies-arrayexpress
ProteomicsAllogeneic antibodies specifically target AML antigen NuSAP1 after bone marrow transplantation
Identifying the targets of immune response after allogeneic hematopoietic cell transplantation (HCT) promises to provide relevant immune therapy candidate proteins. We used protein microarrays to serologically identify Nucleolar and Spindle Associated Protein 1 (NuSAP1) and Chromatin Assembly Factor...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-15255 | biostudies-arrayexpress
UnknownSpecific Class I HLA Supertypes but Not HLA Zygosity or Expression Are Associated with Outcomes following HLA-Matched Allogeneic Hematopoietic Cell Transplant: HLA Supertypes Impact Allogeneic HCT Outcomes.
Not available
S-EPMC8015676 | biostudies-literature
GenomicsImmunogenicity of autologous and allogeneic human primary cholangiocyte organoids
Immunogenicity of autologous and allogeneic human primary cholangiocyte organoids
PRJNA1066756 | ENA
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