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ProteomicsThe small heat shock protein Alpha-Crystallin B shows neuroprotective properties in a glaucoma animal model
Aim of this study was the evaluation of Alpha-crystallin B and its potential neuroprotective properties in an experimentalanimal model of glaucoma with subsequent analysis of possible altered downstream markers in a complex mass spectrometric approach.
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2017-11-28 | MSV000081755 | MassIVE
GenomicsTANGO2 binds crystallin alpha B and its loss causes desminopathy
TANGO2 binds crystallin alpha B and its loss causes desminopathy
PRJNA1157732 | ENA
TranscriptomicsRegulation of the Mycobacterium tuberculosishypoxic response gene encoding alpha-crystallin
Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic condit...
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-05 | E-GEOD-8639 | biostudies-arrayexpress
ProteomicsEffects of alpha-crystallin gene knockout on zebrafish lens development
The alpha-crystallin small heat shock proteins contribute to the transparency and refractive properties of the vertebrate eye lens and prevent the protein aggregation that would otherwise produce lens cataracts, the leading cause of human blindness. There are conflicting data in the literature as to...
ORGANISM(S): Danio Rerio 
PXD030918 | panorama
Genomics
Loss of alpha-Ba-crystallin, but not alpha-A-crystallin, increases age-related cataract in the zebrafish lens
PRJNA1105232 | ENA
UnknownThe Small Heat Shock Protein α-Crystallin B Shows Neuroprotective Properties in a Glaucoma Animal Model.
Not available
S-EPMC5713386 | biostudies-literature
TranscriptomicsTANGO2 binds crystallin alpha B and its loss causes desminopathy
Mutations in the TANGO2 gene cause an autosomal recessive disorder characterised by developmental delay, stress-induced episodic rhabdomyolysis, and cardiac arrhythmias along with severe metabolic crises. Although TANGO2 mutations result in a well characterised disease pathology, the function of TAN...
ORGANISM(S): Homo sapiens 
2025-04-21 | GSE276499 | GEO
ProteomicsDisordered region encodes α-crystallin chaperone activity toward lens client γD-crystallin
Small heat-shock proteins (sHSPs) are a widely expressed family of ATP-independent molecular chaperones that are among the first responders to cellular stress. Mechanisms by which sHSPs delay aggregation of client proteins remain undefined. sHSPs have high intrinsic disorder content of up to ~60% an...
ORGANISM(S): Escherichia coli 
2023-01-31 | PXD035668 | Pride
Hspb5 Small heat shock proteins Crosslinking Bpa 
UnknownTANGO2 binds crystallin alpha B and its loss causes desminopathy.
Not available
S-EPMC12144310 | biostudies-literature
UnknownAn examination of alpha B-crystallin as a modifier of SOD1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis.
Not available
S-EPMC3971727 | biostudies-literature
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