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ModelsYazdjer2019 - reinforcement learning-based control of tumor growth under anti-angiogenic therapy
This model is based on: Reinforcement learning-based control of tumor growth under anti-angiogenic therapy Authors: Parisa Yazdjerdi, Nader Meskin, Mohammad Al-Naemi, Ala-Eddin Al Moustafa, Levente Kovacs Abstract: Background and objectives: In recent decades, cancer has become one of the most fata...
2024-09-02 | BIOMD0000000821 | BioModels
ProteomicsExtracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy
Anti-angiogenic anticancer therapies possess immune-stimulatory properties by counteracting pro-angiogenic molecular mechanisms. We report that tumor endothelial cells ubiquitously overexpress and secrete the intermediate filament protein vimentin through type III unconventional mechanisms. Extracel...
ORGANISM(S): Homo sapiens (Human) 
2022-03-29 | PXD024426 | Pride
Vegf Angiogenesis Human Vimentin Cancer Anti-angiogenic therapy 
GenomicsThree-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
PRJNA735135 | ENA
UnknownAngiogenic signaling pathways and anti-angiogenic therapy for cancer.
Not available
S-EPMC10175505 | biostudies-literature
ModelsHutchinson2016 - Vascular phenotype identification and anti-angiogenic treatment recommendation
This is a spatially averaged multiscale mathematical model of tumor angiogenesis. The model describes the dynamics of VEGF, Ang1, Ang2, and PDGF, coupled with those of mature and immature endothelial cells and pericyte cells.
2019-11-13 | MODEL1911130007 | BioModels
GenomicsRNA sequencing of blood-brain barrier (BBB) microvessels from mice with orthotopic GBM showing the benefit of triple therapy combining anti-immune checkpoint therapy with dual-anti angiogenic therapy.
RNA sequencing of blood-brain barrier (BBB) microvessels from mice with orthotopic GBM showing the benefit of triple therapy combining anti-immune checkpoint therapy with dual-anti angiogenic therapy.
PRJNA535500 | ENA
UnknownNew Anti-Angiogenic Therapy for Glioblastoma With the Anti-Depressant Sertraline.
Not available
S-EPMC11497491 | biostudies-literature
UnknownAnti-Angiogenic Therapy in the Treatment of Non-Small Cell Lung Cancer.
Not available
S-EPMC7699985 | biostudies-literature
UnknownAnti-angiogenic therapy increases intratumoral adenovirus distribution by inducing collagen degradation.
Not available
S-EPMC3443547 | biostudies-literature
TranscriptomicsMast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B
Resistance towards anti-angiogenic therapy (AAT) still represents a substantial clinical challenge. We report here that tumor-infiltrating mast cells (MC) are powerful mediators decreasing efficacy of AAT in mice and cancer patients. They act in a cell-extrinsic manner by secreting granzyme B, which...
ORGANISM(S): Mus musculus 
2017-09-15 | GSE89395 | GEO
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