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MetabolomicsUntargeted Metabolomics To Ascertain Antibiotic Modes of Action
Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially rapid and cost-effective means of identifying modes of action of drugs whose effects are mediated through changes in metabolism. Metabolomics...
2017-06-16 | MTBLS464 | MetaboLights
MetabolomicsMetabolomic analysis of the mechanism of action of yerba mate extract on Salmonella Typhimurium
Background: Salmonella Typhimurium is a gram-negative enteropathogen that infects millions worldwide; the rapid emergence of antibiotic resistant strains has heightened the urgency of developing effective treatment for this pathogen. Previous studies have demonstrated that the aqueous extract of yer...
2017-02-16 | MTBLS359 | MetaboLights
MetabolomicsMacrophage-mediated antibiotic evasion and competitive dominance of mcr-3-carrying Escherichia coli

Mobile colistin resistance (mcr) genes undermine the efficacy of last-line polymyxin antibiotics, and the global prevalence of mcr-3 continues to rise despite reduced colistin use. Here, we show that mcr-3-positive Escherichia coli (E. coli) confers a survival advantage by reprogramming macrophag...

2026-05-30 | MTBLS13550 | MetaboLights
ProteomicsA Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa
Gram-negative bacterial infections are causing increasing levels of morbidity due to the rise of resistance to established antibiotics. New antibiotic classes with distinct molecular mode of action are therefore required. Recently, a family of macrocyclic peptidomimetics was discovered that target t...
ORGANISM(S): Pseudomonas Aeruginosa Pao1 (ncbitaxon:208964) 
2020-02-04 | MSV000084898 | MassIVE
ProteomicsPredictive Signatures of 19 Antibiotic-Induced Escherichia coli Proteomes
Identifying the mode of action (MOA) of antibacterial compounds is the fundamental basis for the development of new antibiotics, and the challenge increases with the emerging secondary and indirect effect from antibiotic stress. Although various omics-based system biology approaches are currently av...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2020-10-09 | MSV000086253 | MassIVE
MetabolomicsMulti-omics uncovers formononetin's protection against antibiotic-induced liver injury via microbiota-metabolite-transcriptome coordination

Tetracycline antibiotics (TETs) cause hepatotoxicity via gut-liver axis disruption and oxidative stress. This study evaluated whether formononetin (FMN), a natural isoflavone, alleviates TET-induced liver injury through microbiota-metabolite-transcriptome coordination. Using network toxicology an...

2025-10-17 | MTBLS13161 | MetaboLights
MetabolomicsMulti-omics uncovers formononetin's protection against antibiotic-induced liver injury via microbiota-metabolite-transcriptome coordination

Tetracycline antibiotics (TETs) cause hepatotoxicity via gut-liver axis disruption and oxidative stress. This study evaluated whether formononetin (FMN), a natural isoflavone, alleviates TET-induced liver injury through microbiota-metabolite-transcriptome coordination. Using network toxicology an...

2025-10-14 | MTBLS13138 | MetaboLights
ProteomicsPISA Assay of B1 antibiotic on Neisseria gonorrhoeae
Study on antibiotic B1 and for target identification and mode of action characterization on Neisseria gonorrhoeae Strain, using Proteome Integral Solubility Alteration (PISA) Assay
ORGANISM(S): Neisseria gonorrhoeae 
2026-01-19 | PXD063107 | Pride
Proteomics Lc-ms Mode of action Antibiotic Target id Bacteria Pisa assay 
ProteomicsA Peptidomimetic Antibiotic Interacts with the Periplasmic Domain of LptD from Pseudomonas aeruginosa
Gram-negative bacterial infections are causing increasing levels of morbidity due to the rise of resistance to established antibiotics. New antibiotic classes with distinct molecular mode of action are therefore required. Recently, a family of macrocyclic peptidomimetics was discovered that target t...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2018-06-21 | PXD008577 | Pride
Dia Thermo q-exactive plus Pseudomonas Peptidomimetic antibiotic Lpt complex Gram-negative bacteria Photo crosslinking Molecular mode of action Lc-ms/ms 
TranscriptomicsA compendium of antibiotic-induced transcription profiles reveals broad regulation of P. multocida virulence genes
Treatment of bacteria with antibiotics at or close to the inhibitory concentration leads to specific transcriptional responses often affecting target genes and targets pathways. A dataset of transcriptional profiles (compendium) induced by antibiotics with known mode-of-action (MoA) can be used to g...
ORGANISM(S): Pasteurella multocida 
2008-06-01 | E-GEOD-10051 | biostudies-arrayexpress
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