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MetabolomicsTransgenic Tobacco Plants Expressing Synthetic Peptides: A Functional and Structural Analysis for Pathogen Resistance
The emergence of multidrug-resistant pathogens poses a significant threat to human health and agriculture. Current antimicrobial strategies against phytopathogens are often ineffective, failing to ensure food security while contributing to environmental pollution. Synthetic antimicrobial peptides (A...
2025-09-25 | MTBLS12255 | MetaboLights
MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsABCF Protein-Mediated Resistance Shapes Bacterial Responses Based on Antibiotic Type and Concentration
Antibiotic resistance (ARE) ABCF proteins are widespread, genome-encoded resistance factors in Gram-positive bacteria that rescue ribosomes stalled by antibiotics. In this study, we integrate genetic, proteomic, metabolomic, and biochemical approaches to reveal that ARE5 subfamily proteins, TiaA and...
ORGANISM(S): Streptomyces coelicolor 
2025-07-28 | PXD063714 | Pride
Streptomyces coelicolor Are acbf proteins Antibiotic resistance 
ProteomicsSuccinylome-controlled antibiotic resistance in MRSA - Succinylome
A sucC and a sucD mutant from the Nebraska Transposon Mutant Library (NTML, Strain NE569 and NE1770) were found to be susceptible to cefoxitin and oxacillin when other mutations in TCA cycle genes did not affect their resistance to these antibiotics. The SucC strain (Strain NE569) accumulated Succin...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
2021-03-02 | MSV000086971 | MassIVE
ProteomicsSuccinylome-controlled antibiotic resistance in MRSA - Global proteome
A sucC and a sucD mutant from the Nebraska Transposon Mutant Library (NTML, Strain NE569 and NE1770) were found to be susceptible to cefoxitin and oxacillin when other mutations in TCA cycle genes did not affect their resistance to these antibiotics. The SucC strain (Strain NE569) accumulated Succin...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
2021-03-02 | MSV000086976 | MassIVE
ProteomicsMechanisms of antibiotic resistance to enrofloxacin in uropathogenic Escherichia coli in dog
Escherichia coli (E. coli) urinary tract infections (UTIs) are becoming a serious problem both for pets and humans (zoonosis) due to the close contact and to the increasing resistance to antibiotics. Great progress has been made in the discovery of novel antibiotics to counteract E. coli pathogens. ...
ORGANISM(S): Escherichia coli 
2015-06-05 | PXD002000 | Pride
Escherichia coli Enrofloxacin Antibiotic resistance Urinary tract infections 
ProteomicsGenome- and proteome-wide analysis of lysine acetylation in Vibrio vulnificus Vv180806 reveals its regulatory roles in virulence and antibiotic resistance
V. vulnificus is an emergent pathogen and causes deadly septicemia in human. Protein acetylation regulates many important biological processes in bacteria. In this study, we identified the first lysine acetylome of V. vulnificus based on the whole-genome sequence of a cefoxitin-resistant strain isol...
ORGANISM(S): Vibrio vulnificus VV 
2020-12-01 | PXD020376 | Pride
Vibrio vulnificus  whole genome sequencing  acetylome  virulence  antibiotic resistance 
TranscriptomicsCollateral sensitivity of antibiotic resistant bacteria to antimicrobial peptides
Cationic antimicrobial peptides (CAPs) are promising novel alternatives to conventional antibacterial agents, but the overlap in resistance mechanisms between small-molecule antibiotics and CAPs is unknown. Does evolution of antibiotic resistance decrease (cross-resistance) or increase (collateral s...
ORGANISM(S): Escherichia coli 
2018-03-29 | GSE96706 | GEO
ProteomicsBeyond self-resistance: ABCF ATPase LmrC is a signal-transducing component of an antibiotic-driven signaling cascade hastening the onset of lincomycin biosynthesis
In natural environments, antibiotics are an important instrument of inter-species competition. At subinhibitory concentrations, they act as cues or signals inducing antibiotic production: however, our knowledge of well-documented antibiotic-based sensing systems is limited. Here, for the soil actino...
ORGANISM(S): Streptomyces lincolnensis 
2021-08-18 | PXD026093 | Pride
Streptomyces lincolnensis Lmrc Resistance Lincomycin 
ProteomicsIdentification of antibiotic resistance proteins via MiCId's augmented workflow. A mass spectrometry-based proteomics approach
Fast and accurate identification of pathogenic bacteria along with the identification of antibiotic resistance proteins is of paramount importance for the treatment of patients and public health. While mass spectrometry has become an important technique for these purposes there is a lack of mass spe...
ORGANISM(S): Pseudomonas aeruginosa Klebsiella pneumoniae Escherichia coli 
2022-06-09 | PXD026634 | Pride
Identification of antibiotic resistance proteins Bacteria identification Mass spectrometry 
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