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We identify a novel microbiota-driven anti-hypertensive mechanism mediated by Achyranthes bidentata (Ab) extract and gut microbe Dubosiella sp.. Using a hypertensive mouse model induced by L-NAME and a high-salt diet, we show that Ab extract significantly ameliorates hypertension and renal damage...

2025-04-02 | MTBLS12017 | MetaboLights

Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, and placental tissue. Although some studies indicate that micropl...

2026-02-05 | MTBLS13850 | MetaboLights
Based on the observation that arachidonic acid represses interferon beta induced transcriptional activation of hCXCL10, hIL12b and IDO1a in THP1 cells and MDMs within 3 h post treatment. This experiment was designed to find other transcripts effected in a similar fashion.
ORGANISM(S): Homo sapiens 
Essential fatty acids (FA) are not only energy-rich molecules; they are also an important component of the membrane bilayer and recently have been implicated in induction of fatty acid synthase (FAS) and other genes. Using gene chip analysis, we have found that arachidonic acid (AA), an omega-6 fat...
ORGANISM(S): Homo sapiens 
Although Candida species, more specifically C. albicans, are the most common pathogenic yeasts, little is known about the mechanism involved in eicosanoid production, a virulence factor in these organisms. This is an important area of research which may aid in the understanding of the complex intera...
ORGANISM(S): Candida albicans 
Natural killer cells were exptracted from PMBCs of healthy donors, exposed to arachidonic acid, Il-2, both, or ascites and their expression changes identified via RNAseq (QuantSeq).
ORGANISM(S): Homo sapiens 
Yangyinqingfei Decoction (YYQFD), a traditional Chinese prescription, is well known in the treatment of diphtheria and lung-related diseases in clinic. However, the underlying mechanism how to treat lung-related diseases remains unclear. In the present study, the intervention effect of YYQFD on PM2....
ORGANISM(S): Mus musculus (Mouse) 
2022-12-22 | PXD037163 | Pride
Functional role of platelet-activating factor (PAF) induced arachidonic acid release
ORGANISM(S): Homo sapiens 
Arachidonic acid (ARA) treated and control oocytes in 3 replicates were subjected to the 6-plex TMT labeling, HP-RP fractionation, and LC-MS/MS analysis.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD018753 | Pride
Monocyte derived macrophages were exposed to arachidonic acid, IL6 or both.
ORGANISM(S): Homo sapiens 
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