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MetabolomicsThe role of FYCO1-dependent autophagy in lens fiber cell differentiation.

FYCO1 (FYVE and coiled-coil domain containing 1) is an adaptor protein, expressed ubiquitously and required for microtubule-dependent, plus-end-directed transport of macroautophagic/autophagic vesicles. We have previously shown that loss-of-function mutations in FYCO1 cause cataracts wit...

2024-03-24 | MTBLS206 | MetaboLights
TranscriptomicsActivation of autophagy by starvation and mTOR inhibition in three human cell lines
The aim of the project was to characterize changes in gene expression that are associated with induced autophagic flux. We engineered HeLa, HEK 293 and SH-SY5Y cell lines to express tandem-fluorecent LC3 (tf-LC3). The ratio of the red and green fluorophores indicated how much of the LC3 is in the ac...
ORGANISM(S): Homo sapiens 
2022-08-25 | E-MTAB-12020 | biostudies-arrayexpress
GenomicsTranscriptomic analysis reveals autophagy flux variation within mouse pancreatic cancer organoids
Transcriptomic analysis reveals autophagy flux variation within mouse pancreatic cancer organoids
PRJNA608184 | ENA
ProteomicsGlobal analysis of impact of Atg5 mutation on steady-state protein levels
This experiment analyzes the global impact of Atg5-/- mutation on steady-state protein levels by a standard SILAC experiment. WT+vector cells were grown in isotopically labeled media for multiple passages in order to fully label the proteome. Unlabeled Atg5-/- cells and labeled WT+vector cells were ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080752 | MassIVE
ProteomicsTemporal Proteomics During Neurogenesis Reveals Large-scale Proteome and Organelle Remodeling via Selective Autophagy
Raw mass spectrometry data associated with the following paper: Temporal Proteomics During Neurogenesis Reveals Large-scale Proteome and Organelle Remodeling via Selective Autophagy. DOI:10.1016/j.molcel.2021.10.001 Related to Figure1D: AO3335-AO3345 Related to Figure4B: Day0 (AO3379-3390); Day4 (AO...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-08-09 | MSV000087961 | MassIVE
ProteomicsGlobal analysis of protein degradation rates in wildtype, Atg5-/- and Atg7-/- primary human fibroblasts
In this project, we employed a dynamic mass spectrometry-based proteomic approach to obtain global maps of basal autophagic flux in human primary fibroblasts (HCA2-hTert). The data provide a comparison of protein degradation rates between wildtype and autophagy deficient (Atg5-/- and Atg7-/-) cells....
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080694 | MassIVE
GenomicsAutophagy flux during human aging is sex- and cell type-specific, and is associated with physical fitness
Autophagy flux during human aging is sex- and cell type-specific, and is associated with physical fitness
PRJNA1468278 | ENA
GenomicsAutophagic flux blockade under hypocapnia reveals CO₂-sensitive regulation of autophagy-lysosome homeostasis
Autophagic flux blockade under hypocapnia reveals CO₂-sensitive regulation of autophagy-lysosome homeostasis
PRJNA1460351 | ENA
UnknownPRRSV utilizes MALT1-regulated autophagy flux to switch virus spread and reserve.
Not available
S-EPMC11587858 | biostudies-literature
UnknownImpaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms.
Not available
S-EPMC11262231 | biostudies-literature
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